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Abstract: SA-PO218

Low Bone Density as a Risk Factor for Depressive Symptoms in Elderly Patients With Non-Dialysis Dependent CKD

Session Information

Category: Bone and Mineral Metabolism

  • 402 Bone and Mineral Metabolism: Clinical

Author

  • Lee, Dong-Young, Seoul Veterans Hospital, Gangdong-gu, Seoul, Korea (the Republic of)
Background

Chronic kidney disease (CKD) is a common disease especially among older people. Moreover, major depressive disorder is one of the most common comorbid conditions in persons with CKD. Both conditions can predispose morbidity and mortality We aimed to evaluate the etiology of CKD and comorbid depression by investigating bone disorders that are observed in persons affected by both CKD and depression.

Methods

We conducted a cross-sectional study with a total of 646 patients with CKD. Depressive symptoms were defined as a score on the K-BDI II greater than 11. We compared the sociodemographic factors, kidney function, markers for CKD-Mineral and Bone Disorder and bone mineral density according to the depressive symptoms. We conducted a multivariate logistic regression analysis to calculated adjusted odd ratios and 95% confidence interval for depressive symptoms in patients with CKD.

Results

Individuals with CKD and depressive symptoms was associated with lower level of education attained, living alone, exercising less, low 24-hour urine phosphorus, and low bone density. Depressive symptoms were significantly associated with low bone density in lowest parts (1.55 [1.06-2.29]) and in total hip (1.72 [1.17-2.53]) even after adjusting for diabetes mellitus, hypertension, kidney function, proteinuria, age, sex, smoking, and body mass index.

Conclusion

Low bone density was identified as a risk factor for depressive symptoms in elderly patients with non-dialysis chronic kidney disease.

ORs and 95% CI between depressive symptoms and low bone density in participants with non-dialysis-dependent CKD