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Abstract: SA-PO336

Lab Abnormalities Can Be Seen as Early as 3 Months Prior to Hospitalization and Mortality Among Malaysian Dialysis Patients

Session Information

Category: Dialysis

  • 701 Dialysis: Hemodialysis and Frequent Dialysis

Authors

  • Ozawa, Yusuke, Davita Malaysia, Kuala Lumpur, Malaysia
  • Ting, Tze Luo, Davita Malaysia, Kuala Lumpur, Malaysia
  • Koh, Pao Kuen, Davita Malaysia, Kuala Lumpur, Malaysia
  • Yahya, Rosnawati, general hospital kuala lumpur, Kuala Lumpur, Malaysia
  • Tan, Li Ping, Davita Malaysia, Kuala Lumpur, Malaysia
Background

Data on associations between lab parameters with death and hospitalization among dialysis patients in Malaysia are limited. This study attempted to identify the blood test items with the highest impact on hospitalization and death.

Methods

We hypothesized that blood test monitoring parameters would affect the risk of being hospitalized and / or dying due to cardio/cerebrovascular events, fluid overload and infections. Patient data was extracted from 40 Davita dialysis clinics across Malaysia from January to December 2021. Variables of interest were Hemoglobin, Phosphate, Albumin, Calcium, Potassium, and Sodium. Data was analysed using 1. Sample Variance test, 2. Sample T-Test, and 3. One way Anova analysis. Regression analysis was done in order to devise a model that would predict mortality.

Results

A total of 774 patients were identified with data available for analysis, 515 patients were not hospitalized. 259 patients were hospitalized with 341 hospitalization events. Of the 259 hospitalized patients. 131patients died within three months of admission giving a yearly mortality rate of 16.9%.

Significant differences in mean values were observed in hospitalized patients and death as early as 3 months predating their hospitalization. These were seen in hemoglobin, albumin, calcium, potassium values. A model incorporating hemoglobin, albumin and calcium values was formulated that was able to predict the risk of mortality in 3 months.

Conclusion

Lab abnormalities were prevalent as early as 3 months prior to hospitalization events and were associated with hospitalization and death. Variables that were significantly different were hemoglobin, albumin, calcium and potassium. Sodium values were significantly differently only when death was analyzed as the outcome. A model that incorporated hemoglobin, albumin and calcium was able to predict the risk of death in 3 months.

Differences between hospitalized and non-hospitalized patients and Death
CategoryHB(P-value)Phos(P-value)Alb(P-value)Ca(P-value)K(P-value)Na(P-value)
Non-hospitalized patients10.851.823239.1952.2445.25136.2
Hospitalized patients9.87(0.00)1.781(0.25)39.371(0.00)2.1716(0.00)5.01(0.01)136.3(0.67)
Death9.283(0.00)1.7383(0.08)36.8(0.00)2.09(0.00)4.78(0.00)135.6(0.06)

Funding

  • Commercial Support