Abstract: TH-PO766
Sexual Dimorphism in AKI Outcomes: Does Menopause Tie the Match?
Session Information
- Sex and Reproductive Factors in Kidney Health
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: Women's Health and Kidney Diseases
- 2100 Women's Health and Kidney Diseases
Authors
- Acosta-Ochoa, Maria Isabel, Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
- Coca, Armando, Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
- Lorenzo, Arturo, Hospital Clinico Universitario de Valladolid, Valladolid, Castilla y León, Spain
Background
Many studies focus on gender differences when suffering AKI, some reporting that female sex could be protective against AKI adverse outcomes, this “protection” could be lost in menopause due to the absence of estrogen among other female hormones. We studied a cohort of individuals suffering from AKI and compared hard outcomes between female and masculine patients older than 55 years.
Methods
Retrospective cohorts’ study, of nephrology ward and consultation, AKI severity was categorized by KDIGO-2012 criteria; we included all patients ≥55 y, analyzed clinical variables and compared the rates of occurrence of the hard outcomes length of hospital stay (LOS), need for dialysis (HD), dialysis dependence at discharge (DDD), and in-hospital mortality (IHM) between groups.
Results
We included 1135 individuals. 70% were male, these patients were older and had a higher Charlson’s Index because they suffered more frequently of COPD, cancer, and peripheral arterial disease among other; women were hospitalized more frequently in medical wards. Table 1A summarizes our findings. We found no statistically significant differences in LOS, HD, DDD and IHM. In Table 1B we summarize the results between groups.
Conclusion
In our study we found that males were older and had a worst Charlson’s Index, and we found no statistically significant differences in the studied hard outcomes between males and females. In conclusion, women in the range of age of menopause (≥55 y) that suffer an episode of AKI do not differ significantly from males in the occurrence of hard clinical and renal outcomes, but males have worst clinical characteristics.