Abstract: TH-PO875
Peri and Para-Renal Fat Tissue and Risk of CKD in Morbid Obese Patients
Session Information
- CKD: Epidemiology, Risk Factors, Prevention - I
November 03, 2022 | Location: Exhibit Hall, Orange County Convention Center‚ West Building
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2201 CKD (Non-Dialysis): Epidemiology‚ Risk Factors‚ and Prevention
Authors
- Smiliansky, Natasha, UDELAR, Hospital de Clinicas, Montevideo, Uruguay
- San Román, Sofia, UDELAR, Hospital de Clinicas, Montevideo, Uruguay
- Ottati, Gabriela, UDELAR, Hospital de Clinicas, Montevideo, Uruguay
- Bruno, Gustavo, UDELAR, Hospital de Clinicas, Montevideo, Uruguay
- Garau, Mariela, UDELAR, Hospital de Clinicas, Montevideo, Uruguay
- Noboa, Oscar A., UDELAR, Hospital de Clinicas, Montevideo, Uruguay
- Etchegoimberry, Veronica, UDELAR, Hospital de Clinicas, Montevideo, Uruguay
Background
Obesity is known as a global pandemic. Multiple studies had determined obesity as an independent risk factor to the initiation and progression of CKD. The measurement of peri and para-renal fat thickness could reflect the visceral fat accumulation associated with kidney function impairment. The aim of this study is to determine the association of para and peri-renal ultrasonographic fat thickness (PUFT) with some cardiovascular and kidney damage markers in morbid obese patients.
Methods
This study was performed with morbid obese patients in bariatric surgery preoperative evaluation. The sonograms were performed by a single technician, to decrease the inter operator variability. It was measured the perirenal fat thickness from the inner side of the abdominal wall to the external edge of each kidney with a convex transducer (3-5 MHz), this measurement was taken twice to insure results. The average of the sonographic measurements to both sides was defined as PUFT
Results
44 patients were analyzed, 86.4% of the population studied were women, with a mean age of 45 (±11.2) years. 65.9% of the patients were hypertensive and 36.4% diabetic. The average BMI was 50.4 (± 8.1) in a range between 35 and 71.6 kilogram square meter.
The PUFT was correlated with BMI (p=0.007) and with visceral fat thickness (p<0.001) with a significance level of 0.05. Albuminuria and PUFT were correlated (p=0.006) even in non-diabetic patients (p=0.018). Estimated glomerular filtration rate (eGFR) was no correlated with PUFT (p=0.735), but when categorizing individuals according to eGFR (< 60 ml/min, between 60-120 ml/min, >120 ml/min), there was a correlation between hyperfiltration patients and PUFT (p=0.0039). Spearman correlation was performed.
When correlating uricemia and PUFT through Pearson's r coefficient, the value was 0.316, (p=0.047), indicating that there is a weak association. The PUFT did not show association with TC, LDL, HDL or TG.
Conclusion
The sonographic perirenal fat thickness (PUFT) measurements could be considered as an accessible and least invasive method to predict kidney damage in morbid obsess patients. It has an equivalence to BMI and other traditional anthropometric indexes as an accurate parameter of visceral fat thickness
Funding
- Other NIH Support