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Abstract: TH-PO399

Total Kidney Volume (TKV) Is Associated With Health-Related Quality of Life (HRQoL) Among Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Session Information

Category: Genetic Diseases of the Kidneys

  • 1101 Genetic Diseases of the Kidneys: Cystic

Authors

  • Mucsi, Istvan, University Health Network, Toronto, Ontario, Canada
  • Hassan, Muhammad Taaha, University Health Network, Toronto, Ontario, Canada
  • Lee, Seung Heyck, University Health Network, Toronto, Ontario, Canada
  • Khowaja, Saima, University Health Network, Toronto, Ontario, Canada
  • He, Ning, University Health Network, Toronto, Ontario, Canada
  • Hillier, David, University Health Network, Toronto, Ontario, Canada
  • Khalili, Korosh, University Health Network, Toronto, Ontario, Canada
  • Pei, York, University Health Network, Toronto, Ontario, Canada
Background

ADPKD is the most common hereditary kidney disease and imposes significant physical and emotional burden on affected patients. The association of health-related quality-of-life (HRQoL) with disease severity markers (DSMs) including total kidney volume (TKV) has been assessed in a few previous studies, but results were inconclusive, in part due to small sample size. In this cross-sectional study we assessed the association between TKV and domains assessed by the short for (SF)-36 questionnaire in a large cohort of patients with ADPKD recruited in Toronto between January 2017 to December 2021.

Methods

Participants completed the study questionnaire that included questions about sociodemographic characteristics and the SF-36 questionnaire. Clinical data was abstracted from medical records. eGFR was estimated from serum creatinine using the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation. All study patients had their TKV measured by MRI and completed a comprehensive PKD1 and PKD2 mutation screen. In addition to assess the association between HRQoL scores and TKV, both as continuous variables, we also generated binary HRQoL variable defining poor HRQoL as the lowest quartile; this quartile then was compared to the rest of the sample.

Results

Of the 306 participants (mean[SD] age 49[15] years) 45% were male. Mean (SD) eGFR was 79(27) ml/min/1.73m2, 12 (4%) of participants had eGFR <30, no patients were on dialysis. Median (interquartile range [IQR]) TKV was 567 (338-933) ml, 149 (49%) had TKV > 1000 ml.
Of the SF-36 domains physical function (rho=-0.28, p<0.001) general health perception (rho=-0.19, p<0.001), bodily pain (rho-0.13, p=0.02) and the physical component score (rho=-0.26, p<0.001) correlated with TKV. Mutation class was not associated with HRQoL domains. In multivariable regression models (adjusted for age, sex and eGFR) TKV was significantly associated with the general health perception domain.

Conclusion

In patients with ADPKD, TKV was significantly correlated with several HRQoL SF-36 domains. Some of these associations were confounded by age and eGFR, but poor general health perceptions remained independently associated with TKV.

Funding

  • Government Support – Non-U.S.