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Abstract: TH-PO819

Relationship Between Serum Klotho Levels and Physical Function in a Community-Based Cohort

Session Information

Category: Health Maintenance‚ Nutrition‚ and Metabolism

  • 1400 Health Maintenance‚ Nutrition‚ and Metabolism


  • Arroyo, Eliott, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Narayanan, Gayatri, Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Coggan, Andrew R., Indiana University Purdue University Indianapolis, Indianapolis, Indiana, United States
  • Moe, Sharon M., Indiana University School of Medicine, Indianapolis, Indiana, United States
  • Lim, Kenneth, Indiana University School of Medicine, Indianapolis, Indiana, United States

Sarcopenia is a degenerative skeletal muscle disease involving the loss of muscle mass and function that can progress into decreased physical function. Beyond exercise and physical activity interventions, there are limited options for the treatment of sarcopenia. Therefore, identifying potential modifiable targets for the treatment of sarcopenia is critically important. Emerging data indicates that the anti-aging protein Klotho may play a key role in regulating sarcopenia and physical function. Herein, we sought to examine the relationship between serum Klotho levels and physical function in a well-validated community-based cohort.


We conducted an exploratory analysis utilizing data from the “Musculoskeletal Function, Imaging and Tissue Resource Core (FIT Core) study” cohort that enrolled ambulatory men and women in Central Indiana aged 5 years and over. All patients underwent comprehensive physical performance assessment and self-reported physical activity questionnaire.


A total of 80 healthy participants (age=49 [18] years) were stratified into four age groups (n=20, 10 [50%] men per group): 20-35 years, 35-50 years, 50-65 years, and ≥65 years. Subjects were further grouped into Low and High performers based on the z-scores for grip strength and number of chair stands completed in 30 seconds. Klotho levels were significantly lower in the ≥65 years group (703.0±189.3 pg/mL) compared to 20-35 years group (916.1±284.8 pg/mL; p=0.03). Despite significantly higher grip strength, number of chair stands completed in 30 seconds, gait speed, distance walked in 6 minutes, and self-reported physical function (SF-36 and PROMIS PF CAT), no significant differences were observed in Klotho levels between the Low and High performers in any age group.


Our findings suggest that Klotho levels decline with increasing age but are not associated with declines in physical function in a healthy community-based cohort. Studies evaluating the relationship between impaired physical function and Klotho levels in patients with chronic kidney disease (CKD), a known state of Klotho deficiency, are warranted.


  • Other NIH Support