ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

learn more

Contact ASN

1401 H St, NW, Ste 900, Washington, DC 20005


The Latest on X

Kidney Week

Please note that you are viewing an archived section from 2022 and some content may be unavailable. To unlock all content for 2022, please visit the archives.

Abstract: SA-PO797

Understanding Anxiety in Potential Living Donors and Its Association With Actual Donation

Session Information

Category: Transplantation

  • 2002 Transplantation: Clinical


  • Waterman, Amy D., Houston Methodist, Houston, Texas, United States
  • Maghen, Ariella, Community Memorial Health System, Ventura, California, United States
  • Balliet, Wendy, Medical University of South Carolina, Charleston, South Carolina, United States
  • Weng, Francis L., Cooperman Barnabas Medical Center, Livingston, New Jersey, United States
  • Graviss, Edward A., Houston Methodist, Houston, Texas, United States
  • Nguyen, Duc T., Houston Methodist, Houston, Texas, United States
  • Bobu, Alexis, Houston Methodist, Houston, Texas, United States
  • Gaber, Ahmed Osama, Houston Methodist, Houston, Texas, United States
  • Peipert, John D., Northwestern University, Evanston, Illinois, United States

Potential donors (PDs) considering Living Kidney Donations (LD) may experience emotional distress surrounding donation and consequently drop out. Using longitudinal cohort data, we examined anxiety at onset of donor evaluation, characteristics associated with higher anxiety, and whether higher anxiety was associated with actual LD.


PDs from 5 transplant centers were surveyed on their attitudes, knowledge of LD, and a PROMIS® 4-item anxiety short form (normative T score mean of 50, higher scores mean higher anxiety). Participants were followed up to 12 months from evaluation to determine if they donated. Multivariable logistic regression models were used to identify characteristics associated with mild anxiety or higher (T score ≥55) and LD.


2184 individuals were surveyed, of which 407 (18.6%) donated a kidney. Participants were White (50.3%), female (61.5%). The median T-score was 46.8 (IQR: 39.4, 54.8); 19.7% (n=424) had T scores ≥55. Anxiety T-scores did not vary by race/ethnicity (p=0.77). Lack of support for donation [odds ratio (OR): 2.25; 95% CI: 1.29, 3.95], having a close familial recipient (OR: 1.72; 1.07, 2.79), and other factors were associated with higher anxiety (Table 1). Compared to those with less anxiety, those patients with higher anxiety were more likely to report that they would prefer that someone else donate (19% vs. 7.5%, P<.001) and had a 39% reduction in odds of actually donating (OR: 0.61; 95% CI: 0.38, 0.97).


Higher anxiety, particularly when the kidney recipient is a family member, was associated with a reduced likelihood of LD. PROMIS Anxiety should be considered as a screening tool for PD along with LD tailored interventions to reduce anxiety and support withdrawal from donation.


  • Other NIH Support