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Abstract: FR-PO676

Images of Sea Blue Histiocytosis in Lupus Nephritis

Session Information

Category: Glomerular Diseases

  • 1303 Glomerular Diseases: Clinical‚ Outcomes‚ and Trials

Author

  • Wen, Jin, Hunan Provincial People's Hospital, Changsha, Hunan, China
Introduction

Sea blue histiocytosis (SBH) is a rare disease characterized by the deposition of abundant sea-blue histiocytes in various organs, most of which is regarded as a hereditary disorder. The association between SBH and lupus nephritis (LN) has never been reported before. Herein, we present a series of images of the deposition of SBH in the bone marrow of an adult woman with LN.

Case Description

A 32-year-old Chinese female was diagnosed with systemic lupus erythematosus (SLE) and LN for twelve years. The significant manifestations were recurrent fever with rash, proteinuria, hematuria, blood cell reduction (leukopenia, thrombocytopenia, and hemolytic anemia), and strong positive ANA and ds-DNA antibodies. She has also suffered from paravertebral infection with mycobacterium xenopi for two years, which was detected by the next-generation sequencing with paravertebral tissue. She has been under anti-mycobacterial therapy for two years. One month ago, the deposition of SBH was obtained in the bone marrow. The whole-exome sequencing (WES) of the patient and her parents has been done by Kindstar Global Company to exclude the primary hematologic hereditary disease.

Discussion

To our knowledge, this is the first case of SBH and LN. Secondary SBH could be diagnosed according to the typical images of SBH in the bone marrow and the negative result of the WES examination. However, the association between SBH and LN remains unknown, and there is another possibility that SBH is associated with non-tuberculous mycobacterial infection.