Abstract: TH-PO0872
Hepatitis A-Induced Glomerulonephritis: A Case Presentation
Session Information
- Glomerular Case Reports: Potpourri
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Rosales Montalvo, Alondra A, American University of Antigua, Coolidge, St George, Antigua and Barbuda
- McMasters, Morgan, Florida International University Herbert Wertheim College of Medicine, Miami, Florida, United States
- Green, Dollie F., Florida International University Herbert Wertheim College of Medicine, Miami, Florida, United States
Introduction
We present a unique case linking hepatitis A virus (HAV) infection with glomerulonephritis (GN), highlighting a rare extrahepatic complication of HAV. GN is an immune-mediated kidney disease often associated with infections, autoimmune conditions, and other immunologic triggers, although its association with HAV remains poorly understood.
Case Description
A 36-year-old Cuban descendant male with a history of hypertension was evaluated for persistent proteinuria noted on routine urinalysis and intermittent frothy urine. His medical history revealed a hospitalization in Cuba for dark urine, abdominal pain, and jaundice in 2014, with a diagnosis of mononucleosis and viral hepatitis at that time, though specific HAV markers were not documented. Under our care, laboratory tests showed an abnormal urinalysis with microscopic hematuria and proteinuria, elevated total complement (Ch50), and a reactive Hepatitis A total antibody, confirming past infection. A renal ultrasound demonstrated normal kidney echogenicity with a 2mm non-obstructive stone. Given the patient’s HAV history and the findings of immune dysfunction, an immune-complex-mediated GN secondary to HAV was considered. Management included dietary protein restriction, antihypertensive therapy with angiotensin receptor blockers and calcium channel blockers, and close monitoring of renal function.
Discussion
Although HAV typically causes self-limited hepatic illness, this case raises awareness of its potential role in GN through immune complex formation. Available literature and case reports suggest that immune-complex glomerular deposition may be an under-recognized sequela of HAV infection, although the exact pathophysiologic mechanism remains unknown. This case emphasizes the need for clinicians to obtain detailed inquiries of social history and to consider prior HAV infection as a possible contributor to GN, particularly in patients with unexplained proteinuria and hematuria. Further studies are warranted to clarify this association, inform management strategies, and potentially guide diagnostic and therapeutic approaches for patients with similar presentations.