Abstract: FR-PO0114
Management of Immune-Related Adverse Event-Associated Urinary Tract Inflammation (irAE-UTI)
Session Information
- AKI: Epidemiology and Clinical Trials
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Author
- Xue, Zhuorui, Peking Union Medical College Hospital, Beijing, China
Background
irAEs that show as urinary tract inflammation are very rare, with limited understanding.
Methods
We analyzed 10 irAE-UTI cases and 18 IirAE-associated acute kidney injury(ICI-AKI) cases as controls.
Results
The UTI group exhibited urinary tract irritation symptoms, with a higher proportion of patients exhibiting positive urine protein and WBC(P<0.05). Imaging found roughened and thickened bladder wall. Bladder biopsies revealed PD-1-/PD-L1-positive lymphocytes infiltration. Concurrent AKI in UTI patients correlated with higher AKI grades than in AKI group (P<0.05). UTI group received lower cumulative steroid doses showed improvements in urinary tract irritation symptoms and renal function without secondary infections.
Conclusion
Urinary irritation symptoms, elevated urine WBC with negative cultures, and imaging evidence of UTI can diagnose irAE-UTI.
| ICI-UTI(n=10) | ICI-AKI(n=18) | P-value | |
| irAE-AKI grade(n) | 6 | 18 | 0.038 |
| 0 | 4 | 0 | |
| 1 | 0 | 2 | |
| 2 | 3 | 9 | |
| 3 | 1 | 5 | |
| 4 | 2 | 2 | |
| Urinalysis(n) | |||
| protein(+) | 5 | 6 | 0.012 |
| WBC(+) | 7 | 2 | 0.003 |
| BLD(+) | 4 | 5 | 0.677 |
| Total steroid dose(median,mg) | 1470 | 3350 | 0.014 |
| Duration of steroid(d) | 36 | 76 | 0.003 |
| Kidney complete remission | 6 | 10 | 0.162 |