Abstract: FR-PO0511
Real-World Urea Clearance and Adequacy with the Moda-flx Hemodialysis System
Session Information
- Dialysis: Hemodiafiltration, Ultrafiltration, Profiling, and Interdialytic Symptoms
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Rad, Sam, Diality, Irvine, California, United States
- D'Alessandri-Silva, Cynthia J., Diality, Irvine, California, United States
- Khawar, Osman, Diality, Irvine, California, United States
- Jamal, Aamir Z., California Kidney Associates, San Dimas, California, United States
Background
The hemodialysis (HD) population continues to deserve a more rapid pace of technological innovation. Achieving adequacy for dialysis patients requires adequate dialysis flow rates in novel systems and is paramount for dialysis frequency and patient survival and outcomes. The Moda-flx Hemodialysis System™, is a new FDA cleared hemodialysis system with integrated reverse osmosis water purification and prescribing flexibility, offered by a wide range of flow rates allowing high efficiency hemodialysis. This study reports the first real world clearance outcomes.
Methods
Retrospective analysis was conducted on 40 HD treatments from 12 patients in center. Blood flow rates were (Qb = 300-400 mL/min) and dialysate flow rate (Qd = 600 mL/min). Dialyzers included Optiflux F180NRe and F160NRe. Treatments performed thrice weekly. Standard single - pool Kt/V (spKt/V) was calculated and standard weekly Kt/V using a validated standard equation with machine-reported ultrafiltration (UF), pre and post treatment blood urea nitrogen values, time, weight and estimated urea distribution volume.
Results
Thirty-six treatments analyzed had a mean time of 230 minutes (range: 138-240 min). Treatments below 200 minutes were excluded. (n = 4) The mean patient weight was 90.59 kg (range: 59.45-182.25 kg), mean Qb= 334.56 mL/min (range: 300 – 400) and mean Qd = 600 mL/min. The mean UF volume was 2.54 kg per treatment and 100% of treatments reached ≥90% of UF goal. Across all treatments the mean calculated spKt/V was 1.32 (range: 0.64-2.09) and a mean URR of 67.2 % (range: 47.92–82.05%). (Figure 1.) Patients who did not meet adequacy targets had a mean weight of 130 kg.
Conclusion
This real-world analysis demonstrated consistent delivery of dialysis adequacy using a new, clinically flexible device. These results highlight the new Moda-flx Hemodialysis System™ high-efficiency dialysis platform under standardized conditions and support further investigation in broader patient populations and care environments.
Funding
- Commercial Support – Diality