Abstract: SA-PO0777
Systematic Review Exploring Clinical Outcome Measures and Frailty Assessment in Older People Living with ANCA-Associated Vasculitis
Session Information
- Glomerular Research: Design, Registries, Surveys, and Epidemiology
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Nixon, Andrew C., Lancashire Teaching Hospitals NHS Foundation Trust, Preston, England, United Kingdom
- Moore, Louise Rachel, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, England, United Kingdom
- Abarca Sanhueza, Patricio Antonio, Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, England, United Kingdom
- Floyd, Lauren, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, England, United Kingdom
- Morris, Adam, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, England, United Kingdom
- Elsayed, Mohamed Elsayed, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, England, United Kingdom
- Dhaygude, Ajay Prabhakar, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, England, United Kingdom
Background
ANCA-associated vasculitis (AAV) predominately affects older adults. Limited research has explored the impact of older age and frailty on outcomes in this population. To improve the quality of care provided to older persons, the International Consortium for Health Outcomes Measurement (ICHOM) developed standardised set of outcomes measures for older adults. These include outcomes such as frailty, falls, polypharmacy, participation in decision-making, hospitalisation, survival & place of death. Other important outcomes to consider in AAV are infection, cardiovascular disease (CVD) & end stage kidney disease (ESKD).
Methods
A systematic review aimed to 1) identify the clinical outcomes assessed in AAV patients aged ≥60 yrs and 2) determine how frailty is measured and its association with outcomes in this population. A search for relevant published literature was performed using 4 databases up to September 2024. Screening & quality assessment were performed, followed by data extraction & narrative synthesis.
Results
A total of 91 studies were included. Most studies reported mortality (86%), followed by ESKD (54%), infection (41%), CVD (33%) and hospitalisation (23%). Frailty was assessed in only 4 studies and polypharmacy in 1. No studies reported ICHOM outcomes such as falls, place of death or decision-making. Frailty prevalence ranged from 22-47% across 4 studies, which assessed frailty using the Clinical Frailty Scale, Hospital Frailty Risk Score or Claims-based Frailty Index. All explored association between hospitalisation & mortality, but none examined associations with CVD, falls, polypharmacy or person-centred outcomes.
Conclusion
Research in older adults with AAV has largely focused on clinical outcomes such as mortality, infection and ESKD, with little attention to other important outcomes like frailty, falls, polypharmacy, participation in decision-making & place of death. Frailty is common but its true prevalence is unclear and existing frailty tools have not been validated in AAV cohorts. Future research should measure outcomes meaningful to older people with AAV & further work is needed to evaluate diagnostic & prognostic accuracy of frailty assessment methods before recommendations can be made for clinical practice.