Abstract: FR-PO0050
Validation of Gameiro AKI Prediction Score Among Patients with Liver Cirrhosis Admitted to a Tertiary Hospital in the Philippines
Session Information
- AKI: Epidemiology, Risk Factors, and Prevention
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- de Leon, Sarah Camarista, East Avenue Medical Center, Quezon City, NCR, Philippines
- Roberts, Stephen Resureccion, East Avenue Medical Center, Quezon City, NCR, Philippines
- Lim, Marissa Elizabeth L., East Avenue Medical Center, Quezon City, NCR, Philippines
Background
Acute kidney injury among patients with liver cirrhosis imposes poorer prognosis. Early diagnosis is important to provide timely intervention and improve disease outcome. This study validates the accuracy of Gameiro score in predicting AKI in patients with liver cirrhosis.
Methods
This is a descriptive and analytic retrospective cohort study that examined the AKI risk score of patients with liver cirrhosis admitted in a tertiary hospital. Serum creatinine, MELD Na and NLR were the components, with cut-off value of ≥2 predictive of AKI. Diagnostic accuracy index namely sensitivity, specificity, positive predictive value, negative predictive value, and receiver operating characteristics were used to assess the discriminative ability of the test and its individual component.
Results
Out of the 196 liver cirrhosis patients, 127 developed AKI. Hemoglobin, INR, baseline creatinine, NLR, Childs Pugh score and Modified MELD Na were the parameters noted to be statistically significant. Gameiro score with cut-off of ≥2 has a sensitivity of 0.827, specificity of 0.79, PPV 0.906, NPV 0.652 in identifying AKI. The AUROC curve of the risk prediction score was 0.808. Serum creatinine of >0.9 mg/dL was the most powerful component, with AUC of 0.772, while MELD Na has lower AUC at 0.63, and NLR has the least diagnostic value with AUC of 0.524.
Conclusion
This validated the AKI prediction score in liver cirrhosis by Gameiro. It can be clinically useful and guide with early detection, prognostication, and timely intervention and referral in managing the disease, yet a validation through a prospective cohort is recommended.
AUC-ROC of the Gameiro Risk Model at ≥2, S creatinine, Modified
MELD Na, and NLR in prediction of AKI in cirrhotic patients