Abstract: TH-PO0314
Association of Low Transferrin Saturation with Increased Cardiovascular Risks in Patients with CKD: Fukuoka Kidney Disease Registry Study
Session Information
- Hypertension and CVD: Clinical - 1
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Hypertension and CVD
- 1602 Hypertension and CVD: Clinical
Authors
- Iwamoto, Saki, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka Prefecture, Japan
- Nakano, Toshiaki, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka Prefecture, Japan
- Tanaka, Shigeru, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka Prefecture, Japan
- Kitamura, Hiromasa, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka Prefecture, Japan
- Yamada, Shunsuke, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka Prefecture, Japan
- Tsuruya, Kazuhiko, Department of Nephrology, Nara Medical University, Kashihara, Nara Prefecture, Japan
- Ago, Tetsuro, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka Prefecture, Japan
Background
Transferrin saturation (TSAT) is an indicator of iron deficiency and has been associated with poor cardiovascular outcomes in the general population. However, epidemiological evidence on the association between TSAT levels and cardiovascular prognosis in patients with chronic kidney disease (CKD) remains limited.
Methods
A total of 4,333 Japanese non-dialysis CKD patients aged ≥18 years enrolled in the Fukuoka Kidney disease Registry (FKR) Study were prospectively followed for 5 years. Patients were categorized into quartiles according to TSAT levels (Q1: <22%, Q2: 22–28%, Q3: 28–36%, Q4: ≥36%). TSAT was calculated as follows: TSAT = [serum iron concentration / total iron-binding capacity (TIBC)] x 100%. The associations between TSAT levels and the risks of incident heart failure and cardiovascular mortality were examined using Cox proportional hazards models adjusted for potential confounders.
Results
During the follow-up period, 216 participants developed heart failure, and 103 died from cardiovascular events. In the multivariable-adjusted Cox proportional hazards models, patients in Q1 (lowest TSAT quartile) had a significantly higher risk of heart failure than those in Q4 (fully adjusted hazard ratio [95% confidence interval]: 1.93 [1.21–3.09]). A similar association was observed for cardiovascular mortality (hazard ratio [95% confidence interval]: 2.21 [1.12–4.36] for Q1 vs. Q4).
Conclusion
Lower TSAT levels were independently associated increased risks of developing heart failure and cardiovascular mortality among patients with CKD.