Abstract: FR-PO1167
Association Between Kidney Function and Health-Related Quality of Life with Instrument 8 Items (HINT-8): Results from Korea National Health and Nutrition Examination Study, 2019-2023
Session Information
- CKD: Screening, Diagnosis, Serum and Urine Biomarkers, and Scoring Indices
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2301 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Yang, Eunji, Cha Ilsan Medical Center, CHA University College of Medicine, Goyangsi, Gyeonggi-do, Korea (the Republic of)
- Kim, Heung Soo, Myeongi hospital, Hangyang University College of Medicine, Goyangsi, Gyeonggi-do, Korea (the Republic of)
Background
Health-related quality of life (HRQoL) is a major factor to evaluate the patient`s condition. This is the same for patients with chronic kidney disease (CKD), and a number of instruments have been developed to assess quality of life (e.g., EQ-5D, HINT-8). We investigated the association between the decreased renal function and HRQoL according to HINT-8 index in advanced chronic kidney disease from normal renal function(15≤eGFR<90).
Methods
Data were retrieved from the Korea National Health and Nutrition Examination. A total of 6038 patients with advanced CKD from normal renal function were enrolled. HINT-8 instrument is current developed to assess HRQoL. This is consisting of 8 questions(climbing stars, pain, vitality, working, depression, memory, sleep, and happiness). HINT-8 index is calculated by each measurement and were analyzed for association with renal dysfunction.
Results
The total of 6038 patients with advanced CKD from normal kidney function and the rate of patient with reduced kidney function (eGFR≤60) accounted for 10.2% of the total. The mean age of the patients with CKD stage 3, 4 was 73.1 ± 8.5 years, and 55.9% were male. The index of HINT-8 was lower in lower eGFR group (0.79, 0.75, 0.74 in CKD stage 2, 3, 4; p<.0001). In multiple linear regression analyses, the HINT-8 index is higher in better the renal function(B, 3.7; 95% confidence interval (CI) 1.1 – 6.4, p=0.006). The association between HINT-8 index and eGFR was analyzed considering the influence for age, sex, BMI, urine albumin, urine sodium, BUN, histories of hypertension, diabetes, dyslipidemia. When subgroup analysis was performed stratified with sex, histories of comorbidities, there were significant difference with eGFR for the index of HINT-8, suggesting that low HINT-8 index was associated with low eGFR regardless of subgroups.
Conclusion
HINT-8 index is a reasonable and predictable HRQoL instrument for patients with CKD. Assessment and management that of patients with CKD can lead to good prognosis for renal function.