Abstract: FR-PO0250
Comparison of Short- and Long-Term Efficacy of Ultrasound-Guided Percutaneous Radiofrequency Ablation and Parathyroidectomy in Patients on Dialysis with Secondary Hyperparathyroidism
Session Information
- Bone and Mineral Metabolism: Clinical Epidemiology and Outcomes
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Bone and Mineral Metabolism
- 502 Bone and Mineral Metabolism: Clinical
Authors
- Lin, Miao, Fujian Provincial Hospital, Fuzhou, Fujian, China
- Chen, Wenmei, Fujian Provincial Hospital, Fuzhou, Fujian, China
- Zhang, Qiongyin, Fujian Provincial Hospital, Fuzhou, Fujian, China
- Wang, Lian, Fujian Provincial Hospital, Fuzhou, Fujian, China
- Hong, Fuyuan, Fujian Provincial Hospital, Fuzhou, Fujian, China
Background
Previously, we showed that ultrasound-guided percutaneous radiofrequency ablation (RFA) can treat refractory SHPT(Zhang et al Kidney Int Rep). In this study, we compared Short- and Long-Term efficacy of two methods in SHPT management.
Methods
A retrospective analysis was conducted between 2015 and 2022. The preoperative and postoperative changes in iPTH, Ca, and P levels were collected, and the recurrence rate was analyzed.
Results
A total of 144 patients were included, with 109 undergoing RFA and 35 undergoing PTX. The median follow-up was 40.8 months (IQR 28.5–57.6). The incidence of hypocalcemia was significantly lower in the RFA group compared to the PTX group (33.9% vs. 54.3%, p < 0.05). There were no significant difference between the two groups (p > 0.05). Binary logistic regression analysis revealed that postoperative iPTH level was an independent risk factor for recurrence (OR = 1.002, 95% CI: 1.000–1.003, p = 0.01).
Conclusion
Both RFA and PTX significantly reduce serum Ca, P, and iPTH levels in patients with SHPT with no significant difference in recurrence rates.
Table 1.Short-term and long-term data of Short- and Long-Term Efficacy of Ultrasound-Guided Percutaneous Radiofrequency Ablation and Parathyroidectomy in dialysis Patients with Secondary Hyperparathyroidism
| Surgical Procedure | RFA | PTX | P value |
| Preoperative data | blank | blank | blank |
| N | 109 | 35 | blank |
| Age range | 52(42,59) | 48(41,56) | 0.396 |
| Follow-up(months) | 36.96(27.06,54.84) | 59.00(48.00,84.00) | 0.001 |
| Serum calcium（mmol/l） | 2.39±0.02 | 2.57±0.03 | 0.001 |
| Serum phosphorus（mmol/l） | 2.33±0.05 | 2.66±0.07 | 0.423 |
| iPTH（pg/ml） | 1500（990，2274） | 1656（1351，2303） | 0.087 |
| ALP（iu/l） | 231.00（135.75，516.25） | 255.00（178.00，464.00） | 0.266 |
| Short-term Postoperative data | blank | blank | blank |
| Serum calcium（mmol/l） | 1.98±0.02 | 1.86±0.04 | 0.024 |
| Phosphorus（mmol/l） | 1.75（1.33，2.19） | 1.50（1.33，1.76） | 0.396 |
| iPTH（pg/ml） | 255.70（105.05，422.80） | 78.08（21.96，295.70） | 0.001 |
| Long-term Postoperative data | blank | blank | blank |
| Serum calcium（mmol/l） | 2.15±0.41 | 2.27±0.29 | 0.289 |
| Phosphorus（mmol/l） | 1.59±0.60 | 1.96±0.64 | 0.108 |
| iPTH（pg/ml） | 383.71±493.65 | 434.80±372.70 | 0.711 |
| severe hypocalcemia（%） | 33.30 | 54.30 | 0.026 |
| Recurrence Rate（%） | 20.00 | 26.10 | 0.510 |
| blank | blank | blank | blank |