Abstract: FR-PO0503
Hemoadsorption Combined with High-Volume Online Hemodiafiltration: Towards a New Therapeutic Paradigm?
Session Information
- Dialysis: Hemodiafiltration, Ultrafiltration, Profiling, and Interdialytic Symptoms
November 07, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Molina, Pablo, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Vicent Rodriguez, Kerlin Jesús, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Alonso Escudero, Iñigo, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Acevedo, Delia, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Pérez Sánchez, Laura, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Aragón Fernández, Isabel María, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Gandia Ureña, Paula, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Parra Collado, Manuel, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Porcar, Laura, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Galván Barrilero, Elena, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Vizcaino, Belen, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Gonzalez, Mercedes, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
- Sancho, Asunción, Hospital Universitario Doctor Peset, Valencia, Valencian Community, Spain
Background
Although the incorporation of an adsorptive cartridge has been shown to enhance the clearance of uremic toxins in conventional hemodialysis (HD), its efficacy when combined with online hemodiafiltration (OL-HDF) remains uncertain. The aim of this study was to compare the clearance capacity across a broad spectrum of molecular weight solutes of hemoadsorption (HA) using the MG-150 adsorptive resin in combination with postdilution OL-HDF.
Methods
A randomized, cross-over clinical trial was conducted involving stable patients undergoing maintenance HD. Each participant received two 4-hour postdilution high-volume OL-HDF sessions, with and without HA, over two consecutive weeks. OL-HDF was performed using a hydrophilic NV2.1U dialyzer (Toray®, Japan). For HA, the MG-150 cartridge (Biosun Medical®, Baihe Medical Group, China) was connected in series before the dialyzer.
Results
Sixteen patients were included (mean age: 63±15 years; 69% male). The addition of HA was well tolerated and did not interfere with OL-HDF performance, allowing for a mean convective volume of 32.2±3.4 L. The reduction ratios for most of the studied toxins were similar between treatments, except for β2M, which demonstrated a slightly higher reduction with the combined HA and OL-HDF treatment compared to OL-HDF alone (83.8% vs. 82.8%; p = 0.002) (Figure). The incidence of intradialytic symptoms, post-dialysis recovery time, and albumin reduction ratio were comparable between treatments, underscoring the safety and tolerability of the combined HA and OL-HDF therapy.
Conclusion
Although the combination of HA with OL-HDF may represent a promising dialysis strategy by incorporating adsorptive clearance into the well-established diffusive and convective mechanisms of OL-HDF, preliminary data suggest that this combined therapy yields only a modest enhancement in the removal of uremic toxins.
Funding
- Commercial Support – Palex Medical provided the hemoadsorption cartridges used in this study. The company had no role in study design, data collection, analysis, interpretation, or abstract preparation.