Kidney Week

Abstract: PUB035

AKI and Continuous Renal Replacement Therapy in Patients Who Have Undergone Lung Transplantation

Session Information

• Publication Only

Category: Acute Kidney Injury

• 102 AKI: Clinical, Outcomes, and Trials

Authors

• Zavala, Mariana Nayeli, Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, N.L., Mexico

Mariana Nayeli Zavala, MD

• Garza Treviño, Ricardo Abraham, Christus Muguerza Sistemas Hospitalarios SA de CV, Monterrey, N.L., Mexico

Ricardo Abraham Garza Treviño

• Sanchez-Salazar, Sergio Saul, Christus Muguerza Sistemas Hospitalarios SA de CV, Monterrey, N.L., Mexico

Sergio Saul Sanchez-Salazar, MD, PhD

• Olivo Gutierrez, Mara Cecilia, Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, N.L., Mexico

Mara Cecilia Olivo Gutierrez, MD

• Borbolla-Flores, Paola, Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, N.L., Mexico

Paola Borbolla-Flores, MD

• Chavarria-Martinez, Uriel, Christus Muguerza Sistemas Hospitalarios SA de CV, Monterrey, N.L., Mexico

Uriel Chavarria-Martinez, MD, PhD

• Wong-Jaen, Manuel, Christus Muguerza Sistemas Hospitalarios SA de CV, Monterrey, N.L., Mexico

Manuel Wong-Jaen, MD, PhD

• Camacho-Ortiz, Adrian, Hospital Universitario Dr Jose Eleuterio Gonzalez, Monterrey, N.L., Mexico

Adrian Camacho-Ortiz, MD, PhD

• Rizo Topete, Lilia Maria, Christus Muguerza Sistemas Hospitalarios SA de CV, Monterrey, N.L., Mexico

Lilia Maria Rizo Topete, MD

Background

Lung transplantation is a relatively recent medical advancement with rapid growth and increasing patient numbers. Few centers worldwide offer this procedure, with only one active center in Mexico. Complications, particularly acute kidney injury (AKI), are common and can occur before, during, or after surgery. AKI affects 20–90% of lung transplant patients, with around 15% requiring kidney replacement therapy (KRT). AKI increases ICU stay, infection risk, mortality, and may lead to chronic KRT dependency if kidney function does not recover.

Methods

Retrospective and Descriptive study. Were included all patients who performed a lung transplant in Christus Muguerza Hospital from 2018 to May 2023. Data was collected in excel and the descriptive data analysis was performed.

Results

Of the 35 patients transplanted in our hospital, they had a mean age of 54 and 24 were males, mean BMI of 24. In 25 double lung transplant were performed, with a mean cold ischemic time of 300 minutes, 14 patients died during hospitalization, with 40 days as a mean of days of hospitalization, of them 15 needed ECMO and 10 CRRT, being the most common cause of the need for CRRT anuria and fluid overload, and with a mean days under CRRT of 23.

Conclusion

Patients undergoing lung transplantation are at high risk of developing acute kidney injury (AKI), often requiring continuous renal replacement therapy (CRRT). Many also need extracorporeal membrane oxygenation (ECMO), which further increases the risk of renal complications. The combined use of ECMO and CRRT highlights the severity of their condition and the need for specialized, multidisciplinary care.

Digital Object Identifier (DOI)

• doi: 10.1681/ASN.20256wh71m5r