Abstract: INFO08-TH
NEPTUNE: Nephrotic Syndrome Study Network
Session Information
- Informational Posters - 1
November 06, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- No subcategory defined
Author
- Kretzler, Matthias, University of Michigan, Ann Arbor, Michigan, United States
Group or Team Name
- NEPTUNE Consortium.
Description
The Nephrotic Syndrome Study Network (NEPTUNE) is a collaborative, investigational infrastructure of 32 North American sites for conducting clinical and translational research on Focal and Segmental Glomerular Sclerosis (FSGS), Minimal Change Disease (MCD), and Membranous Nephropathy (MN). Adults and children with biopsy-proven FSGS, MCD, or MN are recruited at the time of biopsy. Participants provide a research biopsy core and are followed for 36 months. Children with incident NS without a diagnostic kidney biopsy are followed for up to 5 years. NEPTUNE recently expanded its scope to now include adults and children with Alport syndrome. All participants provide blood, urine, and clinical data at enrollment and annually thereafter, with interim 6-month phone visits. 1113 consented and eligible participants have enrolled to-date. The NEPTUNE Match is designed to develop and test a mechanism for evidence-based clinical trial selection and communication aimed to match the highly heterogeneous NS patient population to clinical trials targeting specific mechanisms activated in their individual disease profiles.
The NEPTUNE Ancillary Studies Program facilitates use of consortium resources to the broad research community. Investigators can apply to obtain biosamples, kidney biopsy images, clinical data, patient-reported outcomes, and genetic and genomic datasets derived from biofluids and renal biopsy tissue. NEPTUNE resources have been utilized in more than 253 studies to date to define glomerular disease presentation, pathobiology and care deliver, see Neptune-study.org for easy access.
Funding
- NIH, NephCure Kidney International