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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Abstract: INFO09-SA

The Inherited and Polycystic Kidney Disease Program at Children's National Hospital

Session Information

  • Informational Posters - 3
    November 08, 2025 | Location: Exhibit Hall, Convention Center
    Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

  • No subcategory defined

Authors

  • Wink, Krista Renee, Children's National Hospital, Washington, District of Columbia, United States
  • Salcedo-Giraldo, Jordy, Children's National Hospital, Washington, District of Columbia, United States
  • Freiman, Andrew, Children's National Hospital, Washington, District of Columbia, United States
  • Dadzie, Nicholas, Children's National Research & Innovation Campus, Washington, District of Columbia, United States
  • Pyle, Louise C., Children's National Hospital, Washington, District of Columbia, United States
  • Gulati, Ashima, Children's National Hospital, Washington, District of Columbia, United States

Group or Team Name

  • IPKD Program Team.
Description

The Inherited & Polycystic Kidney Disease (IPKD) Program at Children’s National Hospital is a pediatric nephrogenetics program for children with kidney disease of known or suspected genetic etiology. This program offers personalized multidisciplinary care by integrating our core services in nephrology with genetic, hepatic, nutrition, and psychosocial services and provides guided referrals to specialized programs. Our designation as a PKD Foundation Pediatric Center of Excellence demonstrates our commitment to the clinical care and education of pediatric PKD patients and their families, and our dedication to advancing PKD research.

We encourage informed participation in research, including:
1) The Genetic Studies of Heritable Kidney Diseases Registry assesses genotype-phenotype correlations to define clinical outcomes and reclassify variants of unknown significance in patients with renal disease.
2) Two active industry-sponsored phase 3b clinical trials for infants (NCT04786574) and children (NCT04782258) diagnosed with autosomal recessive PKD.
3) The PKD Foundation ADPKD Registry (NCT04039061) for patients with ADPKD.
4) Core A: The Hepato/Renal Fibrocystic Diseases Translational Resource (CHOP, NCT: 01401998), led by Dr. Lisa Guay-Woodford, documents the genetic and clinical characteristics of ARPKD and related conditions.

Children's National hosts several core research facilities, notably:
1) The Center for Precision Medicine and Genomics Research encourages collaboration between its interdisciplinary faculty to discover new multisystemic interactions and treatment for rare disorders.
2) The Laboratory and Pathology Research Core hosts a Pediatric Biorepository that facilitates the storage of and access to pediatric biospecimens for research use.

Funding

  • PKD Foundation Otsuka Pharmaceuticals