Abstract: INFO08-SA
The Mayo Clinic PKD Center
Session Information
- Informational Posters - 3
November 08, 2025 | Location: Exhibit Hall, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Genetic Diseases of the Kidneys
- No subcategory defined
Authors
- Sussman, Caroline R., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Yang, Hana, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Elbarougy, Doaa E., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Gregory, Adriana, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Liu, Xiaoyan, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Mann, Zoey, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Sieben, Cynthia J., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Cruz, Conrad, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Lin, Xueying, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Huang, Yan, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Romero, Michael F., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Zhou, Xia, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Dahl, Neera K., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Hogan, Marie C., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Hanna, Christian, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Irazabal, Maria V., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Li, Xiaogang, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Hu, Jinghua, Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Kline, Timothy L., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Torres, Vicente E., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
- Harris, Peter C., Mayo Foundation for Medical Education and Research, Rochester, Minnesota, United States
Description
The Mayo Clinic Robert M. and Billie Kelley Pirnie Polycystic Kidney Disease (PKD) Center translates basic scientific findings into better treatments for people with PKD. The Center includes a team of expert faculty dedicated to both groundbreaking basic research and the delivery of comprehensive care. Mayo Clinic, Rochester was awarded 2 Clinical Centers of Excellence designations by the PKD Foundation for adult and pediatric clinics. Services include innovative treatments and opportunities to participate in clinical trials. We collaborate and share materials, resources, and expertise to advance both academic and industry-sponsored PKD research.The Center has expertise in: Genetics, Epigenetics, Metabolomics, Imaging, and Model Systems. It provides specialized data, reagents, and services in Genetics, Epigenetics, and Metabolomics and plays a critical role in uncovering disease origins and identifying biomarkers. The Center also contains the Cystic Kidney and Liver Disease Biobank, for the collection and distribution of PKD patient samples, and oversees the PKD Foundation ADPKD Mutation Database, which evaluates PKD1 and PKD2 gene variants for pathogenicity. Imaging services include advanced preclinical and clinical imaging protocols using 3D ultrasound, CT, and quantitative MRI. It employs cutting-edge image processing techniques, including radiomics, machine learning, and deep learning, to enable automated and precise analysis of organ volume, cyst number, and size, delivering patient-specific, image-based metrics.The Center maintains and shares PKD models in C. elegans, zebrafish, and rodents. It provides standardized protocols for zebrafish and rodent preclinical testing to evaluate the efficacy of novel therapies and higher-throughput drug screening.The Center also pioneers novel therapeutic approaches, including base editing-mediated gene therapy and RNA-based treatments for PKD. We are also deeply committed to training the next generation of scientists, offering opportunities such as Summer Undergraduate Research Fellowships (supported by an R25 grant) and Postdoctoral Fellowships to nurture emerging talent from undergraduate students to junior faculty.
Funding
- NIDDK, Robert M. and Billie J. Pirnie endowment for kidney research, the Zell Family Foundation, R25 DK101405 to MFR