Kidney Week

Abstract: FR-PO1001

Urinary Extracellular Vesicles and Uromodulin Levels in Postmenopausal Women with History of Preeclampsia May Indicate Subclinical Renal and Cardiovascular Damage

Session Information

• Women's Health and Kidney Diseases
  October 23, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Women's Health and Kidney Diseases

• 2100 Women's Health and Kidney Diseases

Authors

• Dokic, Vladimir, Mayo Clinic Minnesota, Rochester, Minnesota, United States

Vladimir Dokic, MD, PhD

• Vaughan, Lisa E., Mayo Clinic Minnesota, Rochester, Minnesota, United States

Lisa E. Vaughan, MS

• Jayachandran, Muthuvel, Mayo Clinic Minnesota, Rochester, Minnesota, United States

Muthuvel Jayachandran, PhD

• Suvakov, Sonja, Mayo Clinic Minnesota, Rochester, Minnesota, United States

Sonja Suvakov, MD, PhD

• Kattah, Andrea G., Mayo Clinic Minnesota, Rochester, Minnesota, United States

Andrea G. Kattah, MD, MS

• Arriola Montenegro, Jose J., Mayo Clinic Minnesota, Rochester, Minnesota, United States

Jose J. Arriola Montenegro, MD

• Hatamova, Jennet, Mayo Clinic Minnesota, Rochester, Minnesota, United States

Jennet Hatamova

• Garovic, Vesna D., Mayo Clinic Minnesota, Rochester, Minnesota, United States

Vesna D. Garovic, MD, PhD, FASN

Background

Preeclampsia (PE) is complex hypertensive disorder of pregnancy which constitute a leading cause of maternal and perinatal mortality and with its long-term complications can cause premature death in women.This study aimed to examine whether the history of PE causes changes in specific populations of renal cell-derived urinary extracellular vesicles (EVs) and plasma and urinary Uromodulin (UMOD) levels.

Methods

Study participants were postmenopausal women with (n=40) and without (n=40) a history of PE. Urinary EVs analysis was performed by flow cytometer and Uromodulin levels were determined by ELISA tests.

Results

In adjusted analyses, three types of EVs were significantly decreased in women with a PE history compared to those without including: 1) CD90 positive, associated with impaired renal function and regeneration, reduced nephron mass, and accelerated aging; 2) CD133 positive, a marker of both acute and chronic kidney injury and renal vascular injury, and 3) alpha-fucosidase marker positive associated with glycoprotein metabolism abnormalities, renal damage, and bladder cancer. Both plasma and urinary uromodulin levels were significantly reduced in the PE group.

Conclusion

This study has identified specific populations of urinary EVs that may be associated with impaired kidney function and subclinical kidney damage in postmenopausal women with a history of PE. The lower levels of urine and plasma UMOD were, for the first time, associated with a history of PE pregnancy. Together, they can serve as biomarkers of increased risk of renal and cardiovascular diseases in women with a history of PE and may provide novel strategies for their prevention and treatment.