Abstract: FR-PO0514
Apelin-13 Outperforms Asymmetric Dimethylarginine in Predicting Mortality in Patients on Hemodialysis
Session Information
- CKM: Clinical - Trials, Epidemiology, and Biomarkers
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Cardiovascular-Kidney-Metabolic Health
- 602 Cardiovascular-Kidney-Metabolic Health: Clinical
Authors
- Taran, Ferah, TC Saglik Bakanligi Corum Erol Olcok Egitim ve Arastirma Hastanesi, Çorum, Çorum Province, Turkey
- Dogan, Ibrahim, Hitit Universitesi, Çorum, Çorum Province, Turkey
- Eser, Baris, Hitit Universitesi, Çorum, Çorum Province, Turkey
Group or Team Name
- Nephrology Department
Background
Cardiovascular diseases are the most important cause of mortality in hemodialysis (HD) patients. The aim of the study was to evaluate the relationship between serum asymmetric dimethylarginine (ADMA), apelin-13 levels, and mortality in HD patients.
Methods
The study comprised a total of 122 patients receiving HD thrice weekly. Baseline pre-dialysis blood samples were collected and stored at −80°C. Serum ADMA and apelin-13 were measured by ELISA. During the 2-year follow-up, patients who died due to all causes were recorded. Demographic features, baseline biochemical values, ADMA, apelin-13, and other inflammation markers of patients who died and were living were compared at the end of the second year.
Results
During two-year follow-up, 26 patients under HD treatment died. Patients who died and were living were compared. The patients who died were older (P<0.001), their apelin-13, albumin, and phosphorus levels were lower (P=0.007, P=0.025, P=0.031), and LDL-c levels and coronary artery disease rates were higher (P=0.027, P=0.020). Apelin-13 levels were 58.0 (46.0-130.8) ng/L in the patients who died and 121.6 (64.6-182.9) ng/L in the living patients. The ADMA levels of the patients who died were lower but not statistically significant (P=0.070). In univariate logistic regression analysis, age, phosphorus, apelin-13, neutrophil/lymphocyte ratio (NLR), and albumin levels were found to be related to mortality. In multivariate logistic regression analysis, age, phosphorus, apelin-13, and NLR were determined as independent variables in predicting mortality (P=0.007, P=0.016, P=0.017, and P=0.031, respectively).
Conclusion
ADMA did not show significant predictive value, suggesting heterogeneity among endothelial dysfunction markers in HD.
HD Patient Features: Survivors vs Non-survivors
Multivariable Predictors of Mortality in HD