Abstract: FR-PO0277
Exceptional Parental Longevity and Kidney Function Decline in Older Adults
Session Information
- CKD: Omics, Systemic Stressors, and Targeted Pharmacotherapy
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2201 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Alzyood, Laith, Albert Einstein College of Medicine, Bronx, New York, United States
- Gao, Tina, Albert Einstein College of Medicine, Bronx, New York, United States
- Nazar, Nijas, Albert Einstein College of Medicine, Bronx, New York, United States
- Aleksic, Sandra, Albert Einstein College of Medicine, Bronx, New York, United States
- Milman, Sofiya, Albert Einstein College of Medicine, Bronx, New York, United States
- Chen, Wei, Albert Einstein College of Medicine, Bronx, New York, United States
Group or Team Name
- LonGenity
Background
Declining kidney function is common in older adults and increases cardiovascular and mortality risk. Exceptional parental longevity is a heritable trait associated with healthy aging and protects from age-related diseases. We hypothesized that exceptional parental longevity protects from kidney function decline in older adults.
Methods
LonGenity is a cohort study of community-dwelling Ashkenazi Jewish adults (ages 65-94) aiming to identify genetic determinants of familial longevity by comparing offspring of parents with exceptional longevity (OPEL) to offspring of parents with usual survival (OPUS). OPEL was defined as having at least one parent who lived past age 95. This study included 420 participants (OPEL, n=203; OPUS, n=217) with baseline and follow-up creatinine measurements over a median of 5 years (range 4-12 years). Kidney function was assessed using estimated glomerular filtration rate (eGFR), calculated from serum creatinine (CKD-EPI 2021). Kidney function decline was defined as a reduction of >1 mL/min in eGFR per year. Logistic regression tested the association between OPEL and kidney function decline.
Results
Mean age was 74±6 years, 53% were women, 8% had diabetes mellitus, and 42% had hypertension. Median baseline eGFR was 73 (IQR: 62–82) mL/min with no significant difference between OPEL and OPUS. Forty percent had kidney function decline; those participants were older (75±6 vs. 74±5 years; p=0.03) and less likely to be women (p=0.02). In unadjusted analysis, OPEL was associated with lower odds of kidney function decline (OR 0.64, 95% CI 0.43–0.95; p=0.03). This association persisted after adjusting for age, sex, and baseline eGFR (OR 0.6, 95% CI 0.44–0.99; p=0.04) (Table), but became not significant after further adjustment for diabetes mellitus, hypertension, and body mass index (p=0.06).
Conclusion
Exceptional parental longevity may be associated with preserved kidney function in older adults, suggesting genetic mechanisms of kidney resilience against aging.
Acknowledgment
Einstein Nathan Shock Center Pilot and Feasibility Award
Multiple Logistic Regression of Exceptional Parental Longevity with Kidney Function Decline
| Covariate | OR (95%CI) | P |
| OPEL | 0.66 (0.44–0.99) | 0.04 |
| Age, yr | 1.05 (1.01–1.09) | 0.01 |
| Female vs. male | 0.64 (0.43–0.96) | 0.03 |
| Baseline eGFR, 1 mL/min | 1.02 (1.00–1.03) | 0.01 |
OPEL: offspring of parents with exceptional longevity; eGFR: estimated glomerular filtration rate
Funding
- Private Foundation Support