Abstract: SA-PO0817
Lupus Anticoagulant Positivity Is Associated with Reduced Renal Remission in Male Patients with Lupus Nephritis
Session Information
- Glomerular Diseases: Management, Evolving Strategies, and Practice-Changing Advances
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Hamadah, Abdurrahman M., Dubai Academic Health Corporation, Dubai, United Arab Emirates
- Kumar, Dileep, Dubai Academic Health Corporation, Dubai, United Arab Emirates
- Aramram, Ahmed Ameer, Dubai Academic Health Corporation, Dubai, United Arab Emirates
- Siddege, Waleed, Dubai Academic Health Corporation, Dubai, United Arab Emirates
- Gulzar, Kashif, Dubai Academic Health Corporation, Dubai, United Arab Emirates
- Alalawi, Fakhriya Juma Abdulla, Dubai Academic Health Corporation, Dubai, United Arab Emirates
- Alhadari, Amna Khalifa, Dubai Academic Health Corporation, Dubai, United Arab Emirates
Background
Lupus nephritis (LN) represents one of the most severe manifestations of systemic lupus erythematosus (SLE). Although SLE predominantly affects females, male patients often demonstrate more aggressive disease and worse renal outcomes. The impact of lupus anticoagulant (LA) positivity on LN remission among males remains insufficiently studied. In this study, we describe characteristics of male patients with LN and evaluate differences in clinical features and remission outcomes between patients with positive lupus anticoagulant (LNpLA) and those without lupus anticoagulant (LNnoLA).
Methods
Adult male patients with SLE and biopsy-proven LN followed at Dubai Hospital, a large tertiary referral hospital in UAE, between 2009 and 2025 were retrospectively included. Clinical manifestations, laboratory parameters, immunologic markers, renal biopsy findings, treatments, and outcomes were analyzed. Kidney biopsies were classified according to the ISN/RPS 2003 classification. Continuous variables were compared using the independent t-test or Mann–Whitney U test, as appropriate, and categorical variables using the chi-square or Fisher’s exact test. Statistical significance was defined as p<0.05.
Results
Thirty-two male patients were included (mean age 42±12 years). Lupus anticoagulant positivity was identified in 28% (n=9). Constitutional symptoms were the most frequent presentation. ANA and anti-dsDNA positivity occurred in 81% and 69% respectively. Class IV LN was the predominant histologic lesion. Baseline demographic and renal function parameters were comparable between LNpLA and LNnoLA groups. LNpLA patients showed higher prevalence of antiphospholipid antibodies and nephrotic-range proteinuria. Thromboembolic events were observed in both groups but stroke occurred exclusively among LNpLA patients. Remission occurred significantly less frequently in LNpLA patients compared with LNnoLA patients (22% vs 56%, p<0.05).
Conclusion
Among male patients with lupus nephritis, lupus anticoagulant positivity was associated with a reduced likelihood of renal remission. These findings support a potential role for antiphospholipid autoimmunity as a prognostic factor in male LN and may have implications for risk stratification and therapeutic decision-making, although larger prospective studies are needed to confirm and further define this association.