Abstract: SA-PO0271
Babassu Mesocarp Flour Attenuates Contrast-Induced AKI in a High-Risk Wistar Rat Model
Session Information
- AKI: Mechanisms - Cell Signaling
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 103 AKI: Mechanisms
Authors
- Da Fonseca, Cassiane Dezoti, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Dos Santos, Nayara, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
- Miura, Carla Roberta Monteiro, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Rodrigues, Daniely Martins, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
- Prado, Beatriz Santana, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Moitinho, Matheus Santos, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Monteiro, Natália Oliveira, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
- Dos Santos Silva, Ricardo, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Nascimento Filho, Antonio Viana, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Castelli, Alessandra Acquesta, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Davila, Katia De Angelis lobo, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Borges, Fernanda Teixeira, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Aragao Carneiro dos Santos, Alef, Universidade Cruzeiro do Sul, São Paulo, SP, Brazil
- Goes, Miguel Angelo, Universidade Federal de Sao Paulo, São Paulo, SP, Brazil
- Santana-Santos, Eduesley, Universidade Federal de Sergipe, São Cristóvão, SE, Brazil
Background
Babassu mesocarp flour, sourced from the Brazilian Amazon, is a sustainable natural ingredient containing bioactive phenolic compounds and flavonoids with antioxidant properties. Its unique bioactive profile highlights the Amazon’s biodiversity and its potential for innovative health research. This study aimed to evaluate the effects of babassu mesocarp flour on contrast-induced acute kidney injury in an ischemia-reperfusion high risk model in male Wistar rats.
Methods
Total phenolic and flavonoid contents of babassu mesocarp flour were quantified using colorimetric assays. Male Wistar rats were randomly assigned to six groups. Babassu mesocarp flour (60 mg/kg/day, orally) was administered for 7 days. Contrast-induced acute kidney injury (CI-AKI) was induced by bilateral renal ischemia-reperfusion (30 minutes) followed by iodinated contrast administration (iohexol, 6 mL/kg) on day 6. Animals were placed in metabolic cages for 24-hour urine collection, and euthanasia was performed on day 9. Physiological parameters, renal function, and oxidative stress markers were evaluated in blood, urine, and kidney tissue samples. Statistical significance was defined as p<0.05.
Results
Analysis of babassu mesocarp flour confirmed the presence of phenolic compounds and flavonoids. Ischemic animals exposed to iodinated contrast showed significant increases in water intake, urinary output, serum creatinine, serum urea, urinary peroxides, thiobarbituric acid reactive substances (TBARS), and urinary nitric oxide levels compared with the babassu-treated group (p<0.05) (Figure 1).
Conclusion
These findings suggest that babassu mesocarp flour exerts potential nephroprotective effects against contrast-induced acute kidney injury in a high risk Wistar rat model. Therefore, the results of this research may support new care practices aimed at identifying patients with risk factors for kidney disease and envision the use of medicinal plants in the prevention.
Acknowledgment
This study was funded by the National Council for Scientific and Technological Development (CNPq), Brazil, under grant number Universal A 404350/2023-2.
Effect of babassu mesocarp flour treatment on kidney function, oxidative stress after contrast-induced acute kidney injury in I/R model.
Funding
- Government Support – Non-U.S.