Abstract: SA-PO0289
Temporal Trends and Mortality Burden of AKI Complicated by Sepsis in the United States: A 25-Year Retrospective Analysis, 1999-2024
Session Information
- AKI: Epidemiology and Risk Factors
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Maqbool, Farkhanda, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan
- Kuraku, Dileep Raja, Vinnic'kij nacional'nij medicnij universitet imeni Mikoli Pirogova, Vinnytsia, Vinnytsia Oblast, Ukraine
- Bandi, Laxmi Prasanna, Kakatiya Medical College, Warangal, Telangana, India
- Keshapogu, Nagarjuna, Vinnic'kij nacional'nij medicnij universitet imeni Mikoli Pirogova, Vinnytsia, Vinnytsia Oblast, Ukraine
- Younas, Kashf, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan
- Venkatesh, Karthik Kanna, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, PY, India
- Nallagonda, Tarun, Government Medical College Siddipet, Siddipet, Telangana, India
- Balla, Achyuth, Government Medical College Siddipet, Siddipet, Telangana, India
- Thiyagarajan, Ragav Vikraman, Malaysia Medical Council, Federal Territory of Kuala Lumpur, Malaysia
- Chiluveru, Sricharan, Alluri Sitaramaraju Academy of Medical Sciences, Eluru, AP, India
- Khan, Nabiha, Faisalabad Medical University, Faisalabad, Punjab, Pakistan
- Narla, Sai Jahnu Sree Reddy, Paris Regional Medical Center, Paris, Texas, United States
- Tekuru, Yogesh, Saint Louis University, St. Louis, Missouri, United States
- Maqbool, Tehmeena, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan
- Vijayarao, Sree Sindhu, University of Miami Miller School of Medicine, Miami, Florida, United States
Background
Acute kidney injury (AKI) is a frequent and severe complication in hospitalized patients, often serving as a precursor to or occurring alongside systemic infections. The population-level impact of AKI (ICD-10 code N17) when complicated by subsequent sepsis (codes A40-A41) requires updated analysis to identify ongoing disparities and long-term mortality trends in the U.S.
Methods
We conducted a retrospective analysis using the CDC WONDER database to evaluate mortality trends from 1999 to 2024. The study utilized ICD codes N17 (Acute Kidney Injury) as the primary indicator, followed by A40-A41 (Sepsis) to identify relevant cases where AKI was a significant factor in the clinical progression toward septic outcomes. We assessed age-adjusted mortality rates (AAMR), demographic disparities, and geographical variations.
Results
From 1999-2024, there were 447,224 AKI sepsis associated deaths. The age adjusted mortality rate (AAMR) rose from 3.51 to 12.28 per 1,000,000, with an overall AAPC of 5.2% (95% CI 4.5–5.9; p<0.001). Mortality was higher in males (AAMR 14.11) than in females (10.88) in 2024, though females had a slightly higher AAPC. The highest rates occurred in those ≥85 years (AAMR 110.25), with a marked rise in ages 65 to 74 during 2019 to 2022. The South and West had the greatest burden, with similar trends across metropolitan and non metropolitan areas. Long term increases persisted among White and Black populations, and 60.1% of deaths occurred in medical facilities.
Conclusion
AKI followed by sepsis continues to be a major contributor to mortality in the U.S. These findings emphasize the urgent need for early renal protection strategies and targeted interventions to prevent infectious complications in patients with acute kidney injury.
Overall and Sex Stratified Acute Kidney Injury and Sepsis-Related AAMR