Abstract: SA-PO0911
Depression and Mortality Among Prevalent Kidney Stone Formers: NHANES, 2007-2018
Session Information
- Health Maintenance, Nutrition, and Metabolism
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Nizami, Tarek, Brown University Health, Providence, Rhode Island, United States
- Raker, Christina A., Brown University Health, Providence, Rhode Island, United States
- Shringi, Sandipan, Brown University Health, Providence, Rhode Island, United States
- Tang, Jie, Brown University Health, Providence, Rhode Island, United States
Background
Kidney stone disease (KSD) is associated with significant morbidity and may negatively impact psychosocial well-being. Here, we evaluated the association between KSD and depression to determine the prognostic significance of depression on mortality in this unique patient population.
Methods
We analyzed 23,051 adults from NHANES 2007-2018 database, including 2,241 individuals with KSD. Depression was assessed using PHQ-9, a validated diagnostic tool to assess depression severity. Ordinal logistic regression examined the association between KSD and depression. Cox regression models evaluated the association between depression severity and all-cause mortality (ACM) and cardiovascular mortality (CVM), adjusting for demographic and clinical factors (Table).
Results
Moderate-to-severe (ms) depression (PHQ-9≥10) was present in 280/2,241 kidney stone formers (KSF) and 1,797/20,810 non-KSF. Regression analysis showed that KSF had higher odds of depression compared with non–KSF (adjusted OR 1.14; 95% CI, 1.00–1.30). This association was significant in women (adjusted OR 1.32; 95% CI, 1.10–1.59; p=0.004), but not in men (adjusted OR 1.03; 95% CI, 0.87–1.22; p=0.72). No effect modification by age was observed.
There were 316 all-cause deaths and 71 cardiovascular deaths among KSF in this cohort, compared with 1,941 and 472 deaths, respectively, among non-KSF. Among non-KSF, individuals with ms-depression had significantly increased risks of ACM (adjusted HR [aHR] 1.76; 95% CI, 1.43–2.16; p<0.001) and CVM (aHR 2.24; 95% CI, 1.14–2.60; p<0.001). In contrast, among stone formers, ms-depression was significantly associated with ACM (aHR 1.99; 95% CI, 1.24–3.21; p=0.005), but not with CVM (aHR 1.61; 95% CI, 0.60–4.32; p=0.34).
Conclusion
KSD is associated with an increased risk of depression, particularly in women. Depression severity predicts ACM, but not CVM, after adjustment for cardiovascular risk factors. These findings underscore the need for integrated mental health management strategies to improve outcomes in KSD.
Acknowledgment
The authors acknowledge the National Center for Health Statistics for providing access to the National Health and Nutrition Examination Survey (NHANES) data.
Funding
- Private Foundation Support