Abstract: TH-PO0515
IgA Vasculitis Superimposed on IgAN After COVID-19 in Adulthood: A Christmas Special
Session Information
- Glomerular Diseases: IgAN, IgA Vasculitis, and More
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Hashmi, Nooruddin, Rutgers Robert Wood Johnson Medical School Library, New Brunswick, New Jersey, United States
- Appelbaum, Zachary, Rutgers Robert Wood Johnson Medical School Library, New Brunswick, New Jersey, United States
- Mira, Michael, Rutgers Robert Wood Johnson Medical School Library, New Brunswick, New Jersey, United States
Introduction
IgA vasculitis, formerly Henoch Schonlein Purpura (HSP), is a small vessel vasculitis that most commonly affects children and typically presents with palpable purpura, arthritis, abdominal pain, and renal impairment. Symptoms most frequently present in the fall, winter, or spring, likely related to the higher incidence of upper respiratory infections. Although less common in adults, HSP in this population is often associated with more severe clinical manifestations. This disease has been associated with several bacterial and viral infections, including streptococcal, parvovirus B19, parainfluenza, and COVID-19. We present a case of IgA vasculitis superimposed on IgA nephropathy (IgAN) in an adult patient following COVID-19 infection.
Case Description
A 41 year old male presented to the Emergency Department with a worsening rash involving his back and lower extremities. Physical examination revealed palpable purpura. Laboratory studies demonstrated a serum creatinine of 1.5 mg/dL. Urinalysis showed 3+ blood and 2+ protein, with 55 RBCs/hpf, and a urine protein to creatinine ratio of 2100 mg/g. He was initiated on corticosteroid therapy, and a skin and kidney biopsies were subsequently performed. The findings of both biopsies were consistent with IgA vasculitis and IgAN. Review of the chart revealed a 1.5 year history of microscopic hematuria and proteinuria that began after COVID-19 infection in August 2024.
Discussion
IgA vasculitis typically presents in children following a bacterial or viral upper respiratory infection. This case highlights the severity of IgA vasculitis in adults, particularly with respect to kidney involvement. Moreover, this case is an example of IgA vasculitis occurring in the setting of IgAN. Further research is needed to elucidate any association between COVID-19 infection and the development of IgAN IgA vasculitis.