Abstract: TH-PO0102
Kinetics of Serum Trace Elements in Patients on Hemodialysis (HD)
Session Information
- Fluid, Electrolyte, and Acid-Base Disorders: Clinical Research
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Fluid, Electrolytes, and Acid-Base Disorders
- 1102 Fluid, Electrolyte, and Acid-Base Disorders: Clinical
Authors
- Tsuruta, Yukari, Hyogo Medical Univesity, Nishinomiya, Hyogo, Japan
- Kuragano, Takahiro, Hyogo Medical Univesity, Nishinomiya, Hyogo, Japan
Background
Several studies have been reported that imbalance of trace elements in HD related with the risk of cardiovascular disease, anemia, cognitive function, and survival of these patients. This study aimed to clarify the determinant factors of trance elements in HD patients.
Methods
This study was designed as 2 years prospective observational study. 99 patients treated with HD were recruited. We measured blood levels of copper (Cu), zinc (Zn), manganese (Mn), selenium (Se), ceruloplasmin, and magnesium (Mg) every six months. We also evaluated indexes nutritional status (Serum albumin level, Body mass index (BMI), Nutritional risk index for Japanese HD patients (NRI-JH), Geriatric nutritional risk index (GNRI), and Controlling nutrition status (CONUT)).
Results
We found significant (p=0.01) correlation between serum Se and Cu levels in HD patients. In the comparison of nutritional status, serum Se levels were significantly lower in the patients with malnutrition (low BMI or low albumin). Moreover, in high malnutrition risk score group (NRI-JH≥8, GNRI<92, and CONUT ≥5), serum Se levels were significantly lower than other groups. Serum levels of Se significantly (p=0.04) decreased after single HD session. Furthermore, pre-HD serum levels of Se after 6month significantly (p<0.01) decreased. We also found significant correlation between the change amount of nutrition risk score and those of serum Se level over six months (Image 1).
Conclusion
Serum levels of Se significantly decreased after single HD session and significantly decreased over the six-month. On the other hand, baseline serum Se levels were significantly correlated with nutritional status, and there was a significant correlation between changes in nutritional status over six months and serum Se levels. Thees results also suggesting that serum Se levels in HD patients strongly regulated by nutritional status. Further studies are needed to verify the clinical significance of decrease in serum Se in HD patients.