Kidney Week

Abstract: SA-PO0492

Temporal Trends and Disparities in Mortality from CKD with Heart Failure and Cerebrovascular Diseases in the United States, 1999-2024

Session Information

• CKM: Clinical - Screening, Population Management, Care Disparities, and Patient-Centered Outcomes
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Cardiovascular-Kidney-Metabolic Health

• 602 Cardiovascular-Kidney-Metabolic Health: Clinical

Authors

• Narla, Sai Jahnu Sree Reddy, Paris Regional Medical Center, Paris, Texas, United States

Sai Jahnu Sree Reddy Narla, MD

• Kuraku, Dileep Raja, Vinnic'kij nacional'nij medicnij universitet imeni Mikoli Pirogova, Vinnytsia, Vinnytsia Oblast, Ukraine

Dileep Raja Kuraku, MD

• Maqbool, Farkhanda, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Farkhanda Maqbool

• Keshapogu, Nagarjuna, Vinnic'kij nacional'nij medicnij universitet imeni Mikoli Pirogova, Vinnytsia, Vinnytsia Oblast, Ukraine

Nagarjuna Keshapogu, MD

• Younas, Kashf, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Kashf Younas

• Khan, Nabiha, Faisalabad Medical University, Faisalabad, Punjab, Pakistan

Nabiha Khan, MBBS

• Nallagonda, Tarun, Government Medical College Siddipet, Siddipet, Telangana, India

Tarun Nallagonda, MBBS

• Chiluveru, Sricharan, Alluri Sitaramaraju Academy of Medical Sciences, Eluru, AP, India

Sricharan Chiluveru, MBBS

• Thiyagarajan, Ragav Vikraman, Malaysia Medical Council, Federal Territory of Kuala Lumpur, Malaysia

Ragav Vikraman Thiyagarajan, MBBS

• Gangireddy, Hasmitha, Guntur Medical College, Guntur, AP, India

Hasmitha Gangireddy, MBBS

• Maqbool, Tehmeena, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Tehmeena Maqbool

Background

Chronic kidney disease (CKD) frequently coexists with heart failure(HF) and cerebrovascular diseases, markedly increasing mortality risk. Population-level impact requires updated analysis to identify ongoing disparities and long-term trends in the U.S.

Methods

We conducted a retrospective CDC WONDER analysis (1999–2024) using ICD-10 codes N18 (CKD) as the primary indicator, followed by I50 (HF) and I60–I69 (Cerebrovascular Diseases). Age-adjusted mortality rates (AAMR) were stratified by sex, race, census region, and urbanization. Joinpoint regression calculated Annual Percent Change (APC) and Average Annual Percent Change (AAPC) with p<0.05.

Results

From 1999–2024, there were 767,689 CKD–HF–cerebrovascular–associated deaths. The age-adjusted mortality rate (AAMR) rose from 9.80 to 18.70 per 1,000,000 between 1999 and 2012, then declined to 10.71 in 2013, followed by a steady increase to 17.82 in 2021, before decreasing slightly to 16.31 in 2024, with an overall AAPC of 2.22% (95% CI 1.29–3.16; p<0.001). Mortality was consistently higher in males than in females throughout the study period. In 2024, male AAMR was 20.20 vs. female 13.38 per 1,000,000. The highest rates occurred in those aged ≥85 years (AAMR 110.25), with a marked rise in ages 65–74 during 2019–2022. The South (AAPC 2.07%) and West (AAPC 1.91%) had the greatest burden, with similar trends across metropolitan and non-metropolitan areas. Long-term increases persisted among White populations (AAPC 2.62%, p<0.001).

Conclusion

CKD with heart failure and cerebrovascular disease remains a major U.S. mortality contributor. Findings urge early cardiovascular protection and targeted interventions.

Overall and Sex Stratified Chronic Kidney Disease, Heart failure and Cerebrovascular Disease- Related Age- Adjusted Mortality Rate per 100,000 people in the United States, 1999-2024