Kidney Week

Abstract: PUB035

Trends in Mortality Associated with CKD and Diabetes in the United States, 1999-2024: A CDC WONDER Analysis

Session Information

• Publication Only

Category: Cardiovascular-Kidney-Metabolic Health

• 602 Cardiovascular-Kidney-Metabolic Health: Clinical

Authors

• Vijayarao, Sree Sindhu, University of Miami Miller School of Medicine, Miami, Florida, United States

Sree Sindhu Vijayarao, MBBS

• Kuraku, Dileep Raja, Vinnic'kij nacional'nij medicnij universitet imeni Mikoli Pirogova, Vinnytsia, Vinnytsia Oblast, Ukraine

Dileep Raja Kuraku, MD

• Patel, Diya, Gujarat Medical Education and Research Society, Ahmedabad, GJ, India

Diya Patel, MBBS

• Maqbool, Farkhanda, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Farkhanda Maqbool

• Keshapogu, Nagarjuna, Vinnic'kij nacional'nij medicnij universitet imeni Mikoli Pirogova, Vinnytsia, Vinnytsia Oblast, Ukraine

Nagarjuna Keshapogu, MD

• Khan, Nabiha, Faisalabad Medical University, Faisalabad, Punjab, Pakistan

Nabiha Khan, MBBS

• Thiyagarajan, Ragav Vikraman, Malaysia Medical Council, Federal Territory of Kuala Lumpur, Malaysia

Ragav Vikraman Thiyagarajan, MBBS

• Chiluveru, Sricharan, Alluri Sitaramaraju Academy of Medical Sciences, Eluru, AP, India

Sricharan Chiluveru, MBBS

• Narla, Sai Jahnu Sree Reddy, Paris Regional Medical Center, Paris, Texas, United States

Sai Jahnu Sree Reddy Narla, MD

• Nallagonda, Tarun, Government Medical College Siddipet, Siddipet, Telangana, India

Tarun Nallagonda, MBBS

• Venkatesh, Karthik Kanna, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, PY, India

Karthik Kanna Venkatesh, MBBS

• Bandi, Laxmi Prasanna, Kakatiya Medical College, Warangal, Telangana, India

Laxmi Prasanna Bandi, MBBS

• Tekuru, Yogesh, Saint Louis University, St. Louis, Missouri, United States

Yogesh Tekuru, MBBS, MPH

• Younas, Kashf, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Kashf Younas

• Kalluri, Hara Gopal, Alluri Sitaramaraju Academy of Medical Sciences, Eluru, AP, India

Hara Gopal Kalluri

• Maqbool, Tehmeena, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Tehmeena Maqbool

Background

Chronic Kidney Disease (CKD) is a frequent, severe complication in diabetic patients, often preceding cardiovascular and kidney failure. Population-level impact requires updated analysis to identify ongoing disparities and mortality trends in the U.S.

Methods

We conducted a retrospective CDC WONDER analysis (1999–2024) using ICD-10 codes N18 (CKD) followed by E10-E14 (DM). Age-adjusted mortality rates (AAMR) were stratified by sex, race, census region, and urbanization. Joinpoint regression calculated Annual Percent Change (APC) and Average Annual Percent Change (AAPC) with p<0.05.

Results

From 1999 to 2024, there were 101,607 CKD–DM–associated deaths. The AAMR rose from 1.51 to 5.40 between 1999 and 2012, declined sharply to 0.31 in 2014, resurged to 2.16 in 2021, then decreased to 0.54 in 2024, with an overall AAPC of -5.27% (95% CI -20.11 to 12.33; p=0.533). Mortality was consistently higher in males than in females. (0.41 vs. 0.27). Notable spikes occurred in 2011-2012 (male peak 6.95, female peak 4.66) and again in 2021 (male 1.32, female 0.86). The highest rates occurred in those aged ≥85 years (AAMR 110.25), followed by ages 75-84 (AAMR 45.50), with a marked rise in ages 65-74 during 2019-2022. The South (AAPC 2.07%) and West (AAPC 1.91%) had the greatest burden. Long-term increases persisted among White populations (AAPC 2.62%, p<0.001), while Black individuals showed a significant decline (AAPC -10.76%, p<0.001).

Conclusion

CKD with DM remains a major U.S. mortality contributor with a non-linear trajectory. Findings urge early renal protection and targeted interventions.