Abstract: SA-PO0835
Association of Community Respiratory Viral Infections with Nephrotic Syndrome Relapse in Pediatric Patients
Session Information
- Glomerular Diseases: Management, Evolving Strategies, and Practice-Changing Advances
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Moss, Haley Elizabeth, University of California San Diego, La Jolla, California, United States
- Boulil, Zaineb, Rady Children's Health, San Diego, California, United States
- Crane, Clarkson, University of California San Diego, La Jolla, California, United States
- Pong, Alice, University of California San Diego, La Jolla, California, United States
- Carter, Caitlin E., University of California San Diego, La Jolla, California, United States
Background
While upper respiratory infections are hypothesized to be a frequent trigger idiopathic nephrotic syndrome (NS) relapse, limited data exist regarding the association of specific viruses with NS relapse.
Methods
Retrospective chart review of pediatric patients with primary NS treated in San Deigo, CA between 2/29/2016 and 2/29/2020. A Poisson regression with a log link was used to look for associations between community virus prevalence and nephrotic syndrome relapse. Incidence rate ratios (IRR) were created from the exponentiated coefficients.
Results
Population included 142 total patients with primary NS; mean age was 5y (SD 4y) at diagnosis and 7y (SD 5y) at study start, with 88 (62%) identified as male at birth. 320 relapses were experienced by 94 subjects with a median of 1 relapse per patient [IQR 0,4]. 15 relapses had a concurrent viral pathogen panel collected at time of relapse.
Conclusion
Higher rates of nephrotic syndrome relapses were associated with increased community prevalence of parainfluenza infection (IRR 1.03 [CI 1.00-1.05]). Larger studies and patient specific viral panels are required to confirm this association.
| NS patients; n | 142 |
| Age in years on 2/29/16; mean (SD) | 7 (5) |
| Sex; n (%) | Male: 88 (62%) |
| Age in years at NS diagnosis; mean (SD) | 5 (4) |
| # of relapse events during study years; n | 320 |
| # of subjects with any relapse during study years; n (%) | 94 (66%) |
| # of relapses/subject during study years; median [IQR] | 1 [0,4] |
| # of relapses with concurrent viral data | 15 |