Abstract: SA-PO0388
Joint Association of Triglyceride-Glucose Index and Systemic Inflammation Index with Mortality in Cardiovascular-Kidney-Metabolic Syndrome Stages 0-3: NHANES, 1999-2018
Session Information
- CKM: Clinical - Epidemiology and Outcomes
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Cardiovascular-Kidney-Metabolic Health
- 602 Cardiovascular-Kidney-Metabolic Health: Clinical
Authors
- Duo, Lijin, Huazhong University of Science and Technology Tongji Medical College, Wuhan, Hubei, China
- Su, Hua, Huazhong University of Science and Technology Tongji Medical College, Wuhan, Hubei, China
Background
To investigate the combined impact of triglyceride glucose (TyG) index and systemic immune-inflammation index (SII) on mortality risk in patients with cardiovascular-kidney-metabolic (CKM) syndrome.
Methods
This study enrolled 12633 participants with stages 0-3 CKM syndrome at baseline from NHANES. Participants were stratified by the median TyG and SII values. Kaplan-Meier (K-M) curves, multivariate Cox proportional hazards models, and restricted cubic spline (RCS) regression were used to assess their associations with mortality. The interaction between TyG and SII was also evaluated. Subgroup and sensitivity analyses were further conducted to verify result reliability.
Results
Compared with participants with low TyG and low SII, the fully adjusted hazard ratio (HR) for all-cause mortality was 2.01 (95% CI: 1.58–2.56), and for CVD mortality was 2.39 (95% CI: 1.48–3.86) among those with high TyG and high SII. The combination of TyG and SII improved the predictive performance for mortality compared with either biomarker alone. Consistent results were found in subgroup and sensitivity analyses.
Conclusion
TyG index and SII were strongly associated with all-cause and CVD mortality in stage 0–3 CKM syndrome. Their combination effectively improved predictive performance.
Kaplan-Meier curves were constructed to evaluate all-cause mortality (A) and CVD mortality (B) among various TyG-SII subgroups.
Restricted cubic spline analyses of TyG index and SII in relation to all-cause and CVD mortality (A–D).
Funding
- Government Support – Non-U.S.