Abstract: SA-PO0495
Associations of Sociodemographic Factors with Statin Use in US Adults with CKD: A Cross-Sectional Analysis of NHANES, 2013-2020
Session Information
- CKM: Clinical - Screening, Population Management, Care Disparities, and Patient-Centered Outcomes
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Cardiovascular-Kidney-Metabolic Health
- 602 Cardiovascular-Kidney-Metabolic Health: Clinical
Authors
- Chang, Ryan, Baylor College of Medicine, Houston, Texas, United States
- Gregg, Lucile Parker, Baylor College of Medicine, Houston, Texas, United States
Background
Guidelines recommend statin use for people with chronic kidney disease (CKD) ≥50 years old regardless of estimated glomerular filtration rate (eGFR). We assessed the association of social determinants of health (SDOH) with statin use and whether eGFR modified these associations.
Methods
Using cross-sectional data from the National Health and Nutrition Examination Survey, we identified adults aged 50-79 years with CKD, defined as eGFR ≥60 mL/min/1.73 m2 with uACR ≥30 mg/g or eGFR <60 mL/min/1.73 m2. Subgroups were defined by eGFR ≥60 and <60. Multivariable logistic regression assessed associations of SDOH with statin use, adjusted for age, sex, race, survey year, hypertension, aspirin use, coronary artery disease, diabetes, and metabolic dysfunction-associated steatotic liver disease. Multiplicative interaction terms assessed whether eGFR <60 vs. ≥60 modified these associations.
Results
We included 2,577 participants, representing 19,719,593 adults with CKD nationwide (mean age 65 years, 54% female). Statins were prescribed for 53% of people with eGFR <60 and 38% of those with eGFR ≥60 (p <0.001). Compared to non-Hispanic white, non-Hispanic Asian race was associated with higher odds of statin use (aOR 1.56, 95% CI 1.12-2.17), while Other race was associated with lower odds (aOR 0.54, 95% CI 0.30-0.96). There was no association of other race/ethnicity categories, education, poverty level, or non-English primary language with statin use in the total cohort. Uninsured status, lack of regular access to care, no recent healthcare utilization, and very low food security were associated with lower odds of statin use (Table). SDOH x eGFR interactions were significant for all exposure variables except race (Table).
Conclusion
Statins are underutilized among adults aged 50-79 with CKD, particularly those with eGFR ≥60. Interventions to improve insurance and access to care should be studied to improve statin use among people with CKD.
| Exposure variable | Level | Main effects | eGFR <60 | eGFR ≥60 | p-value for interaction |
| Insurance status | Uninsured | 0.31 (0.18-0.51) | 0.48 (0.24-0.94) | 0.27 (0.14-0.56) | 0.0003 |
| Regular access to care | No regular access to care | 0.22 (0.08-0.64) | 0.54 (0.07-3.97) | 0.13 (0.05-0.39) | 0.0009 |
| Recent healthcare utilization | No healthcare appointment in last 12 months | 0.10 (0.04-0.24) | 0.25 (0.08-0.79) | 0.05 (0.01-0.19) | <0.0001 |
| Food security category | Full | ref | ref | ref | 0.007 |
| Marginal | 1.06 (0.71-1.58) | 1.13 (0.61-2.10) | 1.01 (0.61-1.68) | ||
| Low | 1.33 (0.97-1.85) | 1.43 (0.89-2.28) | 1.25 (0.76-2.04) | ||
| Very low | 0.60 (0.37-0.96) | 0.72 (0.39-1.33) | 0.54 (0.27-1.11) |
Funding
- Veterans Affairs Support