Abstract: SA-PO0834
Urinary Lactate as a Prognostic Biomarker for Kidney Function Deterioration in Diabetic Kidney Disease
Session Information
- Glomerular Diseases: Management, Evolving Strategies, and Practice-Changing Advances
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Bai, Qiong, Peking University Third Hospital, Beijing, China
- Deng, Zhenling, Peking University Third Hospital, Beijing, China
Background
Lactate, a key metabolic intermediate connecting fatty acid and glucose metabolism, is increasingly recognized for its role in diabetic kidney disease (DKD). Emerging evidence shows high lactate levels worsen DKD metabolic dysregulation. This study aims to explore the relationship between urinary lactate (uLactate) and kidney outcomes in DKD patients, evaluating its potential as a prognostic biomarker.
Methods
We conducted a retrospective analysis of 176 DKD patients diagnosed by renal biopsy. The uLactate concentrations were measured by ELISA. We analyzed the association between uLactate and renal outcomes.
Results
Our findings revealed that the median age of 176 DKD patients was 55.0 years, with a diabetes duration of 10.0 years. Notably, uLactate levels correlated positively with urinary total protein (UTP) and N-acetyl-β-D-glucosaminidase, and negatively with albumin and estimated glomerular filtration rate (eGFR). Furthermore, patients in the high uLactate group (uLactate/Creatinine≥5.24) exhibited a significantly higher incidence of kidney function deterioration (73.8%) compared to the low uLactate group (29.5%), with median survival times of 613 days and 1679 days, respectively. Cox regression analysis indicated a hazard ratio (HR) of 2.115 for kidney function deterioration in the adjusted model in the high uLactate group, with an especially higher HR in patients with UTP <3.5g/d or eGFR≥ 60 ml/min/1.73m2.
Conclusion
Our findings confirm that elevated uLactate is associated with renal function deterioration in DKD patients.This finding supports its candidacy as a prognostic biomarker and emphasizes the importance of lactate metabolism in the pathogenesis of DKD.
Acknowledgment
Q.B designed the study, confirm the authenticity of all the raw data, revised the manuscript and finalized the article. Z.L.D. collected urine samples and detected urianry lactate, and wrote the manuscript.
This work was supported by grants from Peking University Third Hospital (BYSYFY2021025 and BYSYZD2021036), and the National Natural Science Foundation of China Youth Project (82502205).
The Kaplan Meier survival curve for the deterioration of kidney function in DKD patients according to urinary lactate binary classification.