Abstract: SA-PO1017
Remnant Cholesterol as an Independent Risk Factor for Cardiovascular Mortality in Patients on Maintenance Hemodialysis
Session Information
- Hemodialysis: Risk Factors, Epidemiology, and Outcomes
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Bai, Qiong, Peking University Third Hospital, Beijing, China
- Deng, Zhenling, Peking University Third Hospital, Beijing, China
- Wang, Song, Peking University Third Hospital, Beijing, China
Background
Remnant cholesterol (RC) is increasingly acknowledged as a significant causal factor contributing to cardiovascular disease (CVD) and associated mortality. Nonetheless, the link between RC and both all-cause mortality and CVD mortality in patients undergoing maintenance hemodialysis (MHD) remains inadequately defined. This study aims to explore the association between RC and the risk of all-cause and CVD mortality in MHD patients.
Methods
This study included 346 MHD patients from 2010 to 2025 at Peking University Third Hospital. Based on the median RC value, patients were categorized into high RC (RC ≥ 0.72 mmol/l) and low RC (RC < 0.72 mmol/l) groups. Cox regression analysis was employed to identify independent risk factors for all-cause and CVD mortality among MHD patients.
Results
During a median follow-up of 7.1 years (interquartile range 4.2 to 12.2),, there were 118 all-cause deaths, including 64 CVD deaths. The CVD mortality rate was significantly higher in the high RC group compared to the low RC group (35.8% vs 1.16%, P<0.001). Kaplan-Meier survival analysis indicated a significant difference in CVD mortality between the two groups (P<0.0001). Multivariate Cox regression analysis revealed that high RC levels serve as an independent risk factor for CVD mortality (hazard ratio, 26.642; P<0.001). Conversely, elevated RC was not an independent risk factor for all-cause mortality.
Conclusion
Elevated RC was independently predictive of CVD mortality in MHD patients. Our findings underscore the importance of monitoring RC as a potential cardiovascular risk marker in MHD patients to improve risk stratification and guide clinical management.
Acknowledgment
This work was supported by grants from Peking University Third Hospital (BYSYFY2021025 and BYSYZD2021036), and the National Natural Science Foundation of China Youth Project (82502205).
Kaplan-Meier analyses for all-cause mortality (A) and CVD mortality (B) between low and high RC group. RC, remnant cholesterol; low RC, RC<0.72mmol/l; high RC, ≥ 0.72mmol/l.