Abstract: SA-PO0877
Association Between Dietary Magnesium Intake and Kidney Failure and Cardiovascular Outcomes Among Patients with CKD: The CKD-Japan Cohort Study
Session Information
- Health Maintenance, Nutrition, and Metabolism
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Health Maintenance, Nutrition, and Metabolism
- 1500 Health Maintenance, Nutrition, and Metabolism
Authors
- Toida, Tatsunori, Toho Daigaku Iryo Center Ohashi Byoin, Meguro, Tokyo, Japan
- Kurita, Noriaki, Tokai Daigaku, Shibuya, Tokyo, Japan
- Imaizumi, Takahiro, Nagoya Daigaku, Nagoya, Aichi Prefecture, Japan
- Hamano, Takayuki, Nagoya Shiritsu Daigaku Daigakuin Igaku Kenkyuka Igakubu, Nagoya, Aichi Prefecture, Japan
- Nangaku, Masaomi, Tokyo Daigaku, Bunkyo, Tokyo, Japan
- Maruyama, Shoichi, Nagoya Daigaku, Nagoya, Aichi Prefecture, Japan
Group or Team Name
- CKD-JAC Investigators
Background
Magnesium deficiency may contribute to the progression of chronic kidney disease (CKD), but the clinical relevance of dietary magnesium intake remains unclear. We examined the association between dietary magnesium intake and kidney and cardiovascular outcomes.
Methods
We analyzed 2,126 participants with non-dialysis CKD who completed a validated dietary history questionnaire approximately 6 months after enrollment. Dietary magnesium intake was estimated using the validated Brief-Type Self-Administered Diet History Questionnaire (BDHQ) and categorized into quartiles. The highest quartile (Q4) was used as the reference. The primary outcome was kidney failure with replacement therapy (KFRT). Secondary outcomes were cardiovascular disease (CVD), all-cause death, and a composite of CVD or death. Cox proportional hazards models and stratified Fine-Gray models were used, with adjustment for potential confounders. We also adjusted additionally for serum magnesium in a subset of 1,300 participants with available serum magnesium measurements.
Results
Median estimated dietary magnesium intake was 190 mg/day; even patients in the Q4 category had a median intake of 298 mg/day, indicating that most participants did not meet the recommended daily magnesium intake. During the median follow-up of 5.2 years, 823 KFRT events, 180 CVD events, 142 deaths, and 274 composite events occurred. KFRT incidence rates were 9.68, 7.75, 5.76, and 5.47 per 100 person-years in Q1, Q2, Q3, and Q4, respectively. In adjusted Cox models, lower dietary magnesium intake was associated with a higher risk of KFRT: HRs were 1.52 (95% CI, 1.09-2.12) for Q1, 1.48 (95% CI, 1.11-1.98) for Q2, and 1.16 (95% CI, 0.89-1.50) for Q3 compared with Q4. The magnitude of the associations was not attenuated after adjustment for serum magnesium and was consistent with that observed in the stratified Fine-Gray models. No clear associations were observed for CVD, all-cause death, or the composite of CVD or death.
Conclusion
Lower dietary magnesium intake was associated with a higher risk of KFRT in patients with non-dialysis CKD, independent of serum magnesium levels. Further studies are needed to establish optimal intake targets and determine whether magnesium-focused dietary interventions can improve kidney outcomes.
Funding
- Commercial Support – Kyowa Kirin Co., Ltd.