Abstract: TH-PO0741
Visceral-to-Subcutaneous Fat Ratio and AKI in Patients with Scrub Typhus
Session Information
- AKI: Critical Care, CKRT, Cardiorenal Syndromes, and Clinical Outcomes
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Authors
- Jeong, Seung Hee, Presbyterian Medical Center, Jeonju-si, Jeollabuk-do , Korea (the Republic of)
- Lee, Ha-Eun, Presbyterian Medical Center, Jeonju-si, Jeollabuk-do , Korea (the Republic of)
- Oh, Ju hwan, Presbyterian Medical Center, Jeonju-si, Jeollabuk-do , Korea (the Republic of)
- Cho, A young, Presbyterian Medical Center, Jeonju-si, Jeollabuk-do , Korea (the Republic of)
- Sun, In O, Presbyterian Medical Center, Jeonju-si, Jeollabuk-do , Korea (the Republic of)
Background
Visceral to subcutaneous adipose tissue (V/S) ratio is reported to be helpful to predict the development of acute kidney injury (AKI), but its role in scrub typhus-associated AKI is unknown. We aimed to investigate whether V/S ratio assessed by CT was able to predict the development of AKI in patients with scrub typhus.
Methods
Between 2009 and 2024, 300 of 683 patients were diagnosed with scrub typhus at Presbyterian Medical Center who underwent CT. Subcutaneous and visceral adipose tissue areas were quantified at the L4-L5 level. Patients were classified into low V/S ratio (Low-VS, N=146) and high V/S ratio (High-VS, N=154)] based on the VS ratio of 0.65.
Results
The High-VS group were older than the Low-VS group (68.9 vs. 63.1 years, P<0.001) and had more comorbidities such as hypertension (51% vs. 35%, P=0.017) and diabetes (29.2% vs. 9.6%, P<0.001). The High-VS group had higher incidence of complications in respiratory and cardiovascular system. Furthermore, AKI developed significantly more in the High-VS group than in the Low-VS group (33.1% vs 19.9%, p<0.02). The overall incidence of AKI was 26.7%; of which, 18.0%, 7.7%, and 1.0% cases were classified as Risk, Injury, and Failure, respectively. In a multivariate logistic regression analysis, older age, hypertension and higher V/S ratio were significantly associated with AKI.
Conclusion
The high V/S ratio in patient with scrub typhus is significantly associated with the development of AKI.
Table 1. Comparison of baseline characteristics
| Low-VS (n=146) | High-VS (n=154) | P-value | |
| Age (years) | 63.1 ± 14 | 68.9 ± 11 | < 0.001 |
| Male, n(%) | 65 (45) | 83 (54) | NS |
| DM, n(%) | 14 (9.6) | 45 (29.2) | < 0.001 |
| Hypertension, n(%) | 48 (35) | 70 (51) | 0.017 |
| CKD, n(%) | 3 (2.1) | 5 (3.3) | NS |
| Hemoglobin (mg/dl) | 12.4 ± 1.5 | 12.5 ± 1.8 | NS |
| Complications | |||
| Gastrointestinal tract, n (%) | 36 (24) | 24 (14) | NS |
| Respiratory system, n (%) | 27 (19) | 49 (32) | 0.006 |
| Cardiovascular system, n (%) | 23 (16) | 45 (29) | 0.03 |
| Central nervous system, n (%) | 2 (1.4) | 5 (3.2) | NS |
| Acute kidney injury, n (%) | 29 (20) | 51 (33) | 0.007 |
| Leukocyte (×103/ mL) | 7.5 ± 3.8 | 8.2 ± 4.4 | NS |
| Platelet count ( ×103/ mL) | 134± 56 | 140 ± 48 | NS |
| Serum albumin (mg/dl) | 3.5 ± 0.6 | 3.4 ± 0.7 | NS |
| Serum ALT (IU/L) | 135 ± 195 | 125 ± 100 | NS |
| Creatinine (mg/dl) | 1.0 ± 0.5 | 1.2 ± 0.6 | 0.02 |
NS, not significant.