Abstract: FR-PO0567
Prevalence and Clinical Factors Associated with Mitral Annular Calcification in Patients on Maintenance Hemodialysis
Session Information
- CKM: Clinical - Meta-Analyses, Predictive Modeling, Care Delivery, and Safety
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Cardiovascular-Kidney-Metabolic Health
- 602 Cardiovascular-Kidney-Metabolic Health: Clinical
Authors
- Inoue, Takahiro, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Daimon, Masao, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Hirano, Hajime, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Munakata, Yu, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Machinura, Tetsuro, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Mori, Tomomi, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Kawaguchi, Yuki, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Tsuchiya, Ken, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Hoshino, Junichi, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
- Hanafusa, Norio, Tokyo Joshi Ika Daigaku, Shinjuku, Tokyo, Japan
Background
Mitral annular calcification (MAC) is associated with aging, renal failure, and dialysis dependence, and has been linked to mitral valve dysfunction, atrial fibrillation, stroke, and mortality. Cardiovascular calcification is viewed as an active process involving inflammation, uremia, phosphate burden, and mineral metabolism disorders. Yet the prevalence and significance of MAC in maintenance hemodialysis patients are unclear. This study aimed to clarify MAC prevalence and associated clinical factors.
Methods
We retrospectively evaluated 99 maintenance hemodialysis patients who underwent echocardiography at our institution. Patients were divided into a MAC group (n=31) and a non-MAC group (n=68). Clinical characteristics, echocardiographic findings, and laboratory data were compared between groups.
Results
MAC was present in 31 of 99 patients (31.3%). The MAC group was older (70 [64–77] vs. 64 [55–70] years, p<0.001) and had a longer dialysis duration (19 [11–26] vs. 12 [2.8–22] years, p=0.006). Aortic valve calcification (79.3% vs. 50.8%, p=0.012) and moderate or greater aortic stenosis (19.4% vs. 1.5%, p=0.004) were more frequent in the MAC group. Mitral regurgitation severity was also higher (p=0.036). The MAC group had higher CRP levels (0.27 [0.11–0.81] vs. 0.13 [0.048–0.33] mg/dL, p=0.026) and lower albumin levels (3.2 [2.8–3.5] vs. 3.5 [3.1–3.7] g/dL, p=0.030). Ca, phosphate, intact PTH, and hemoglobin did not differ.
Conclusion
The prevalence of MAC among maintenance dialysis patients was 31.3%. MAC was associated with older age, longer dialysis vintage, aortic valve calcification, aortic stenosis, inflammation, and malnutrition. MAC may serve as an important echocardiographic marker reflecting systemic calcification burden as well as inflammatory and malnutritional status in maintenance dialysis patients.
| Variable | MAC (N=31) | Non-MAC (N=68) | P value |
| Age, years | 70 [64–77] | 64 [55–70] | <0.001 |
| Dialysis duration, years | 19 [11–26] | 12 [2.8–22] | 0.006 |
| Moderate or greater AR, % | 3.2% | 0.0% | 0.313 |
| Moderate or greater AS, % | 19.4% | 1.5% | 0.004 |
| Aortic valve calcification, % | 79.3% | 50.8% | 0.012 |
| CRP, mg/dL | 0.27 [0.11–0.81] | 0.13 [0.05–0.33] | 0.026 |
| Albumin, g/dL | 3.2 [2.8–3.5] | 3.5 [3.1–3.7] | 0.030 |
| Phosphate, mg/dL | 4.9 [3.9–5.6] | 5.1 [4.4–5.8] | 0.321 |
| Calcium, mg/dL | 8.7 [8.4–8.9] | 8.5 [8.0–9.1] | 0.594 |