Abstract: TH-PO0614
Patterns and Outcomes of Kidney Diseases in Patients Transitioning from Pediatric to Adult Nephrology Care: A Tertiary Care Single-Center Experience
Session Information
- CKD: Clinical - Guidelines, Biomarkers, Progression, Procedures, Outcomes, and More
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2202 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Alotaibi, Khalid Ayidh, King Abdulaziz Medical City in Riyadh, Riyadh, Riyadh Province, Saudi Arabia
- Iqbal, Junaid, King Abdulaziz Medical City in Riyadh, Riyadh, Riyadh Province, Saudi Arabia
- Aldogiam, Ghada Ali, King Abdulaziz Medical City in Riyadh, Riyadh, Riyadh Province, Saudi Arabia
- Alajlan, Nuha Abdulaziz, King Abdulaziz Medical City in Riyadh, Riyadh, Riyadh Province, Saudi Arabia
- Almalki, Meshal Mohammed, King Abdulaziz Medical City in Riyadh, Riyadh, Riyadh Province, Saudi Arabia
Background
Transition from pediatric to adult nephrology represents a vulnerable period, yet data describing disease patterns and outcomes in this population remain limited. We aimed to characterize the spectrum of kidney disease and early outcomes following transition to adult nephrology care.
Methods
We conducted a retrospective cohort study of 239 patients referred from pediatric to adult nephrology at King Abdulaziz Medical City, Riyadh (2018–2024). Demographic, clinical, genetic, and treatment data were extracted. Kidney outcomes at 1 year were defined as stable CKD, CKD progression, ESKD, or post-transplant. Follow-up status and reasons for non-adherence were also reported. Descriptive statistics, chi-square, and Fisher's exact tests were used; p<0.05 was significant.
Results
The median age at referral was 14 years, 54.4% were male. Referrals from pediatric to adult nephrology increased progressively, peaking in 2023. CAKUT was the most common diagnosis (33.5%), followed by tubular/metabolic disorders (15.5%); glomerular diseases accounted for only 7.9%. Kidney biopsy was performed in 10%, while genetic testing was undertaken in 36.4%, identifying pathogenic variants in 22.6% predominantly involving tubular/metabolic genes (42.6%). 48 (20.1%) patients were hypertensive at the time of referral.
Kidney function was largely preserved at transition (median creatinine 61 µmol/L), with only 3.8% requiring renal replacement therapy, mainly peritoneal dialysis.
At 1 year, 80.3% remained stable, 9.6% progressed, and 5.4% developed ESKD. Peritoneal dialysis remained the predominant renal replacement modality, and kidney transplantation was performed in 2.1%.
Significant factors associated with poor renal outcomes (i.e., progressive CKD and/or need to commence RRT) at one year included non-adherence to follow up (24.3%) and hypertension at the time of referral (p=0.043).
Conclusion
This transition cohort is characterized by a predominance of congenital and genetic kidney diseases. Non-adherence to follow up and presence of hypertension at the time of referral were associated with poor renal outcomes highlighting specific targets for intervention in our population. These findings underscore the need for structured transition programs and targeted follow-up strategies aiming at adolescents and young adults with kidney disease.