Abstract: SA-PO0304
Sex-Related Differences in Incidence and Outcomes of AKI
Session Information
- AKI: Epidemiology and Risk Factors
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Bano, Ruqiyya, Stony Brook University, Stony Brook, New York, United States
- Piret, Sian E., Stony Brook University, Stony Brook, New York, United States
- Brooks, Heddwen L., Tulane University, New Orleans, Louisiana, United States
- Mallipattu, Sandeep K., Stony Brook University, Stony Brook, New York, United States
Background
Acute kidney injury (AKI) is a common condition affecting hospitalized patients. While male sex has been correlated as a risk factor for AKI, our aim was to evaluate if age-related sex disparities exist in AKI development and post-AKI outcomes.
Methods
Using the Stony Brook University (SBU) and Research (RN) TriNetX Networks, inpatient encounters with associated creatinine measurements were queried for individuals 0-89 years of age. AKI diagnosis was assessed using KDIGO definition and ICD-9/10 codes. Mortality was assessed within 90 days of the encounter. Multivariable logistic regression and Cox hazards models were adjusted for demographics (age, race, ethnicity) and comorbidities (hypertension, diabetes, cardiovascular disease, obesity, and chronic kidney disease). Baseline hormone replacement therapy (HRT) was defined as use of estrogens or progestins in females ≥ 55 years of age and use of testosterone in males ≥ 40 years of age prior to their inpatient admission.
Results
Males of any age were more likely to develop AKI in both SBU (OR: 1.26 (95% CI: 1.26 (95% CI: 1.22 – 1.30)) and RN (OR: 1.22 (95% CI: 1.21 – 1.22)) cohorts. Peak odds ratios were seen at 20-29 years in RN (OR: 1.92 (95% CI: 1.90 – 1.95)) and 30-39 in SBU (OR: 1.58 (95% CI: 1.43 – 1.75)). AKI risk increased with age in both cohorts. Males with AKI displayed higher mortality risk (HR: 1.19 (95% CI: 1.18 – 1.20)), while the risk was negligible in SBU cohort. Baseline HRT use was associated with lower AKI risk in females in both SBU (OR: 0.63 (95% CI: 0.56 – 0.71)) and RN (OR: 0.81 (95% CI: 0.80 – 0.83), p < 0.001) cohorts, and similarly in males in both SBU (OR: 0.66 (95% CI: 0.53 – 0.82)) and RN (OR: 0.74 (95% CI: 0.72 – 0.75) cohorts. Both males and females diagnosed with AKI during their hospitalization showed significant decline from discharge eGFR up to 10 years post discharge, compared to non-AKI patients of the same sex in the SBU cohort, with no significant sex-based differences seen in AKI patients.
Conclusion
Incidence of AKI diagnosis is higher in males as compared to females across all age groups, with a peak in odds ratio noted between 20-39 years of age, with significantly higher hazards of mortality seen amongst a large national cohort. HRT use is associated with lower risk of AKI development in both males and females.