Abstract: SA-PO0314
Dialysis-Requiring AKI and Inpatient Outcomes in ANCA-Associated Vasculitis with Pulmonary Involvement
Session Information
- AKI: Epidemiology and Risk Factors
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Velez-Oquendo, Gabriel, Northeast Georgia Health System Inc, Gainesville, Georgia, United States
- Siddiqi, Nabeel, Northeast Georgia Health System Inc, Gainesville, Georgia, United States
- Aggarwal, Deepak K., Northeast Georgia Health System Inc, Gainesville, Georgia, United States
Background
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis with pulmonary involvement carries substantial morbidity. How often dialysis-requiring acute kidney injury (AKI) occurs in this population and how it relates to short-term hospital outcomes is incompletely described at a national level.
Methods
We identified adult hospitalizations (2016–2022) in the Nationwide Inpatient Sample with ICD-10-CM codes for ANCA-associated vasculitis (granulomatosis with polyangiitis), microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis, and a claims-based pulmonary involvement indicator in the same hospitalization. Dialysis-requiring AKI was defined using ICD-10-CM-PCS codes. We assessed demographic and clinical predictors, and primary outcomes including in-hospital mortality, length of stay, and costs. Logistic regression was used to assess factors associated with in-hospital mortality and linear regression was used for LOS.
Results
A total of 20,690 patients were identified in the database. Dialysis-requiring AKI occurred in 10.7% of the hospitalizations. The dialysis-AKI group had higher adjusted odds of acute respiratory distress syndrome (ARDS), hemoptysis, acute respiratory failure, acute pulmonary edema, pneumothorax, and pleural effusion; but diffuse alveolar hemorrhage was too rare in the dialysis cohort to estimate a stable adjusted odds ratio. After adjustment, dialysis-requiring AKI remained associated with higher in-hospital mortality (OR 2.72, 95% CI 2.43–3.05) and mechanical ventilation (OR 5.04, 95% CI 4.57–5.56), approximately 12 additional hospital days, and nearly threefold higher charges.
Conclusion
In this nationwide inpatient cohort of adults with ANCA-associated vasculitis and pulmonary involvement, dialysis-requiring AKI identified a high-burden subgroup with markedly higher mortality, ventilation use, length of stay, and charges. These findings highlight AKI with dialysis as an actionable risk stratum for outcomes research and resource planning.
Primary outcomes of Dialysis requiring AKI secondary to ANCA Vasculitis with pulmonary involvement.