Abstract: FR-PO0280
Intrinsic Capacity as a Measure of Successful Aging and Its Association with Mortality in Adults with CKD
Session Information
- CKD: Omics, Systemic Stressors, and Targeted Pharmacotherapy
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2201 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Larkin, Claire T., University of Illinois Chicago, Chicago, Illinois, United States
- Missikpode, Celestin, University of Illinois Chicago, Chicago, Illinois, United States
- Hannan, Mary F., University of Illinois Chicago, Chicago, Illinois, United States
- Ricardo, Ana C., University of Illinois Chicago, Chicago, Illinois, United States
- Lash, James P., University of Illinois Chicago, Chicago, Illinois, United States
Group or Team Name
- CRIC Study Group
Background
Chronic kidney disease (CKD) is associated with accelerated aging. The World Health Organization has proposed intrinsic capacity as a framework for evaluating healthy aging. This framework has been found to be a reliable predictor of mortality but has not been evaluated in the context of CKD.
Methods
In 2202 CRIC participants, we constructed a successful aging score using the sum of four domains of intrinsic capacity: cognition (assessed by the Modified Mini-Mental State Exam), locomotion (gait speed), psychological (KDQOL-36 Mental Component Summary), and vitality (hand grip). We evaluated the association of the change in the successful aging score over a three-year period (annualized Z score change [range from -4.6 to 2.8] as a continuous variable and by quartiles) with all-cause mortality.
Results
Individuals in the highest successful aging quartile were younger, more likely to be male, White, married, had higher educational attainment, were less likely to have diabetes, and had higher eGFR and lower proteinuria at baseline. Over the three-year period, 53% participants experienced decline in healthy aging score. During median follow-up of 6.2 years, on multivariable analyses, each one-point score increase was associated with a 18% lower mortality risk (Figure, Table).
Conclusion
Intrinsic capacity is a significant predictor of mortality in patients with CKD and may represent a target for interventions.
Association of Successful Aging Score with Mortality
| Events/n | Event Rate per 100 person-yrs | HR (95% CI) | |
| Quartile 1 | 203/553 | 5.36 | Ref |
| Quartile 2 | 164/553 | 4.31 | 0.83 (0.66, 1.04) |
| Quartile 3 | 128/554 | 3.3 | 0.76 (0.60, 0.96) |
| Quartile 4 | 150/553 | 3.88 | 0.78 (0.62, 0.99) |
| Per 1 point increase | -- | -- | 0.87 (0.77, 0.98) |
Adjusted for site, age, sex, race/ethnicity, education, smoking, BMI, systolic BP, diabetes, CVD, ACE/ARB, aspirin, statin, baseline eGFR, and proteinuria
Funding
- NIDDK Support