Abstract: FR-PO1065
Prior In-Center Hemodialysis Exposure and Early Urine Output Trajectory After Peritoneal Dialysis Initiation
Session Information
- Home Dialysis: Modalities, Barriers, Utilization, and Clinical Outcomes
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 802 Dialysis: Home Dialysis and Peritoneal Dialysis
Authors
- Dejman, Adriana, University of Miami Miller School of Medicine, Miami, Florida, United States
- Contreras, Gabriel, University of Miami Miller School of Medicine, Miami, Florida, United States
- Del Castillo Rix, Daniel Sebastian, University of Miami Miller School of Medicine, Miami, Florida, United States
- Sosa, Marie Anne, University of Miami Miller School of Medicine, Miami, Florida, United States
- Duque, Juan, University of Miami Miller School of Medicine, Miami, Florida, United States
Group or Team Name
- Katz Family Division of Nephrology and Hypertension, University of Miami
Background
Residual kidney function, commonly reflected by urine output (UO), is associated with positive outcomes in peritoneal dialysis (PD)
Whether prior exposure to in-center hemodialysis (iHD) is associated with more rapid early UO decline after PD initiation remains unclear
Methods
We conducted a retrospective cohort study of 88 PD patients with serial UO measurements at up to 4 time points after PD initiation. Patients were stratified by prior iHD exposure. The primary outcome was absolute change in UO from T1 to T3, with percent change assessed as a secondary outcome. Linear regression models evaluated the association between prior iHD exposure and change in UO, adjusting for age, comorbidities, and baseline UO. Sensitivity analyses incorporated the time between available UO measurements
Results
The cohort had a mean age of 54.2 ± 13.3 years; 52% were female, 69% were Hispanic, approximately one third had prior exposure to in-center hemodialysis (iHD) before PD initiation. Hypertension was prevalent, and diabetic nephropathy and chronic glomerulonephritis were the leading causes of kidney disease. Baseline urine output (UO) was lower among patients with iHD exposure compared with PD-naïve patients (1366 vs 1720 mL/day)
Residual UO remained relatively preserved during early PD follow-up, with median UO of 1600 (IQR 1200–2000) at T1, 1600 (IQR 1300–2000) at T2, 1500 (IQR 1050–2000) at T3, and 1700 mL/day (IQR 1000–2100) at T4. Mean urine volumes remained stable at approximately 1.55–1.65 L/day across assessments, suggesting preservation of residual kidney function during the transition to PD. Adjusted analyses, prior iHD was not independently associated with accelerated UO decline, and findings were consistent in sensitivity analyses accounting for variable follow-up intervals. PD adequacy was preserved, with a mean Kt/V of 2.47 ± 0.65
Conclusion
In this retrospective cohort of incident PD patients, prior iHD exposure was associated with lower baseline UO but was not associated with accelerated early UO decline after PD initiation. These findings suggest that early UO trajectories after PD initiation may be similar despite prior iHD exposure, although interpretation is limited by cohort size, missing UO data, and variable measurement intervals. Standardized monitoring of kidney function after PD initiation may better characterize UO trajectories and identify patients at risk of RKF loss