Kidney Week

Abstract: SA-PO1237

Beyond Kidney Outcomes: Mental Health and Vulnerability in Onconephrology

Session Information

• Onconephrology: Epidemiological Trends, Risk Stratification, and Clinical Outcomes
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Onconephrology

• 1600 Onconephrology

Authors

• Patricio-Liébana, Marc, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Marc Patricio-Liébana, MD

• Soler, Maria Jose, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Maria Jose Soler, MD, PhD

• Zamora Carrillo, Jorge Ivan, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Jorge Ivan Zamora Carrillo, MD

• Agraz Pamplona, Irene, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Irene Agraz Pamplona, MD, PhD

• Nunez-Delgado, Sara, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Sara Nunez-Delgado, MD

• Sans Atxer, Laia, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Laia Sans Atxer

• León-Román, Juan Carlos, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Juan Carlos León-Román, MD

• López-Martínez, Marina, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Marina López-Martínez, MD

• Bestard, Oriol, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Oriol Bestard, MD, PhD

• Bermejo Garcia, Sheila, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain

Sheila Bermejo Garcia, MD, DrMed, PhD

Group or Team Name

• Servei de Nefrologia

Background

Mental health disorders are common in cancer and CKD, but their burden and prognostic impact remain poorly defined.

Methods

Prospective study of patients evaluated at the Onconephrology Unit between November 2021 and January 2026. Sleep disorders, depression, cognition and anxiety were assessed at baseline, 6 months and 12 months using validated scales. Clinical, analytical and outcome variables were collected. Determinants of vulnerability were explored using univariable and multivariable models. Survival was analysed with Kaplan-Meier curves.

Results

444 patients included; 40.3% women, mean age 68.5 years. Baseline: 9.7% sleep disorder, 33.2% depression, 33.4% cognitive impairment and 34.2% anxiety. Univariable analysis: depression was associated with living in a long-term care facility, cognitive impairment with diabetes, poorer kidney function, older age and long-term care residence. Female sex with anxiety. 6 months: anxiety was associated with female sex, older age and oncological progression. Depression was associated with female sex and oncological progression, anxiety with female sex and renal progression. Multivariable analysis: age was associated with cognitive impairment. Diabetes mellitus and female sex with depression. At 6 months, female sex, age and oncological progression with anxiety, living alone with depression. During follow-up 28% patients died. Patients with kidney or oncological progression showed lower survival. Survival differences were assessed using the log-rank test (p<0.001 both).

Conclusion

Patients attending onconephrology clinics have a high burden of psychological and cognitive vulnerability. Oncological and renal progression are associated with worse outcomes, women appear more vulnerable to depression and anxiety. Systematic longitudinal screening and integrated multidisciplinary care are needed in onconephrology patients.