Kidney Week

Abstract: SA-PO0393

Association Between Plasma Calciprotein Particle Levels and Longitudinal Changes in the Renal Resistive Index in Community-Dwelling Adults

Session Information

• CKM: Clinical - Epidemiology and Outcomes
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Cardiovascular-Kidney-Metabolic Health

• 602 Cardiovascular-Kidney-Metabolic Health: Clinical

Authors

• Kosaki, Keisei, Tsukuba Daigaku, Tsukuba, Ibaraki Prefecture, Japan

Keisei Kosaki, PhD

• Yoshikoshi, Shun, Tsukuba Daigaku, Tsukuba, Ibaraki Prefecture, Japan

Shun Yoshikoshi, PhD

• Mori, Shoya, Tokyo Nogyo Daigaku, Setagaya, Tokyo, Japan

Shoya Mori, PhD

• Matsui, Masahiro, Yokohama Shiritsu Daigaku Fuzoku Byoin, Yokohama, Kanagawa Prefecture, Japan

Masahiro Matsui, PhD

• Nishitani, Natsumi, Koeki Zaidan Hojin Meiji Yasuda Kosei Jigyodan Tairyoku Igaku Kenkyujo, Hachioji, Tokyo, Japan

Natsumi Nishitani, PhD

• Sugaya, Takeshi, Sei Marianna Ika Daigaku, Kawasaki, Kanagawa Prefecture, Japan

Takeshi Sugaya, PhD

• Miura, Yutaka, Jichi Ika Daigaku, Shimotsuke, Tochigi Prefecture, Japan

Yutaka Miura, PhD

• Maeda, Seiji, Waseda Daigaku Sports Kagaku Gakujutsuin, Tokorozawa, Saitama Prefecture, Japan

Seiji Maeda, PhD

• Kuro-o, Makoto, Jichi Ika Daigaku, Shimotsuke, Tochigi Prefecture, Japan

Makoto Kuro-o, MD, PhD

• Yamagata, Kunihiro, Tsukuba Daigaku, Tsukuba, Ibaraki Prefecture, Japan

Kunihiro Yamagata, MD, PhD

Background

Calciprotein particles are mineral-bearing nanoparticles recognized as mediators of vascular toxicity, yet prospective data linking their circulating levels to organ-level hemodynamic deterioration remain scarce. The renal resistive index, measured by Doppler ultrasonography, is a reproducible surrogate of intrarenal and systemic vascular resistance that captures early hemodynamic changes preceding overt renal functional decline. We investigated whether baseline plasma calciprotein particle levels predict longitudinal trajectories of the renal resistive index in community-dwelling adults.

Methods

This analysis drew on the Aging Kidney Study, a prospective observational cohort of community-dwelling adults. We identified 289 participants (mean age 62 ± 11 years) who had undergone at least two renal resistive index assessments during follow-up. Plasma calciprotein particle levels were quantified using a validated gel-filtration chromatography–based method and entered into models as a standardized continuous variable. Longitudinal renal resistive index trajectories were modeled using linear mixed-effects regression, adjusting for prespecified covariates.

Results

Participants with higher baseline plasma calciprotein particle levels demonstrated a significantly steeper rise in renal resistive index over the follow-up period. This association remained robust across progressively adjusted models, suggesting that confounding by traditional cardiorenal risk factors does not fully account for the observed relationship. Sensitivity analyses based on absolute and proportional renal resistive index change, estimated individual slopes, and clinically meaningful worsening thresholds all yielded directionally concordant results.

Conclusion

Elevated plasma calciprotein particle levels are prospectively associated with accelerated renal resistive index progression, suggesting that calciprotein particle–mediated vascular toxicity extends to intrarenal hemodynamic deterioration detectable before overt loss of kidney function. These findings support the pathogenic role of calciprotein particles in age-related vascular decline and highlight circulating calciprotein particle burden as a potentially modifiable hemodynamic risk factor in aging populations.

Acknowledgment

We thank the participants as well as the staff and student members of the University of Tsukuba laboratory for their contributions.

Funding

• Government Support – Non-U.S.