Abstract: TH-PO1205
Thermoregulation During CRRT and Hospital Mortality for Patients Weighing Less Than 10 kg
Session Information
- Pediatric Nephrology: CV Health, CKD, AKI, Dialysis, Transplantation, and Health Services Research
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1800 Pediatric Nephrology
Authors
- Wilson, Madeline A., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Slagle, Cara L., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Starr, Michelle C., Indiana University School of Medicine, Indianapolis, Indiana, United States
Background
Continuous renal replacement therapy (CRRT) is commonly used in critically ill infants and small children. Decreased body temperature after CRRT initiation has been documented, but the association between thermoregulation and outcomes in infants and small children <10 kg treated with CRRT has not been described.
Methods
This was a retrospective, single-center study of subjects <10 kg treated with CRRT from 7/1/2022 to 4/30/2026. Data on demographics, temperatures 4 hours pre- and 6 hours post-CRRT initiation, and outcomes were collected. The independent variable was the occurrence of hypothermia (defined as a temperature <36.0 C) within 6 hours after CRRT initiation. The primary outcome was survival to hospital discharge. Those receiving extracorporeal membrane oxygenation (ECMO) were excluded due to expected temperature stability and high mortality. Infants treated with therapeutic hypothermia for hypoxic ischemic encephalopathy were also excluded. Statistical significance was determined with chi-square tests for categorical variables and Wilcoxon rank sum tests for continuous variables.
Results
22 (53.7%) of the 41 patients included in the study were hypothermic within 6 hours of CRRT initiation (Figure 1). There were no significant differences in patient characteristics between groups. Of the patients who survived the CRRT run (n=30), only 50% of hypothermic patients survived to hospital discharge compared to 100% of euthermic patients (p=0.003).
Conclusion
This single-center retrospective study found that hypothermia is common in small children after CRRT initiation and is associated with a decreased chance of survival until hospital discharge. Our results indicate that thermoregulation after CRRT initiation could be a target for intervention to improve outcomes for patients <10 kg.