Abstract: TH-PO0864
Continuous Venous Oxygen Saturation Monitoring Using a CRRT-Integrated Optical Sensor
Session Information
- Dialysis: Prescription, Physiology, and Treatment Optimization
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Antonowicz, Bailey, University of Michigan Michigan Medicine, Ann Arbor, Michigan, United States
- Elmenini, Jaafar, University of Michigan Michigan Medicine, Ann Arbor, Michigan, United States
- Szamosfalvi, Balazs, University of Michigan Michigan Medicine, Ann Arbor, Michigan, United States
- Rao, Panduranga S., University of Michigan Michigan Medicine, Ann Arbor, Michigan, United States
- Yessayan, Lenar Tatios, University of Michigan Michigan Medicine, Ann Arbor, Michigan, United States
Background
In critically ill patients requiring CRRT, volume overload often necessitates ultrafiltration (UF). However, the lack of real-time physiologic monitoring limits assessment of UF tolerance and may increase the risk of hemodynamic instability. Mixed venous oxygen saturation (SvO2) reflects the balance between systemic oxygen delivery and consumption and may serve as a surrogate marker of cardiac output. Although pulmonary artery catheter (PAC)-derived SvO2 is considered the gold standard, its use is limited by invasiveness and complications. CRRT-integrated optical sensors may allow continuous venous oxygen saturation monitoring through the extracorporeal circuit. This study evaluated agreement between superior vena cava central venous oxygen saturation (ScvO2) measured using a CRRT-integrated optical sensor and SvO2 via pulmonary artery catheter.
Methods
Nine critically ill patients receiving CRRT through internal jugular dialysis access and concurrent PAC monitoring were included. ScvO2 measurements obtained from the CRRT optical sensor and SvO2 measurements from the PAC were collected at matched time points. Agreement between modalities was assessed using Bland-Altman analysis.
Results
Mean age was 65 ± 12 years, and 7/9 (78%) subjects were male. Oligo-anuric acute kidney injury was the indication for CRRT in 7/9 (78%) subjects. At CRRT initiation, 7/9 (78%) subjects were in shock, 8/9 (89%) were receiving vasoactive support, and 7/9 (78%) were receiving inotropic support. Catheter tips were positioned between the superior cavoatrial junction and brachiocephalic veins. Subjects underwent concurrent CRRT and PAC monitoring for 7±6 days. Baseline cardiac index was 2.17±0.71 L/min/m2. A total of 189 paired measurements were analyzed. Bland-Altman analysis demonstrated a mean bias of 7.1% between ScvO2 measured by the CRRT optical sensor and SvO2 measured by PAC, with 95% limits of agreement ranging from −12.3% to 26.4%. Agreement appeared strongest when dialysis catheter tips were positioned near the cavoatrial junction and decreased with more proximal catheter placement.
Conclusion
ScvO2 measured using a CRRT-integrated optical sensor demonstrated moderate agreement with PAC-derived SvO2 in critically ill patients receiving CRRT. These findings suggest that CRRT-integrated optical monitoring may provide a feasible, less invasive approach for continuous hemodynamic assessment during ultrafiltration.