Abstract: SA-PO0658
Neighborhood Deprivation and One-Year Kidney Outcomes in Patients with IgAN
Session Information
- Glomerular Diseases: Clinical, Outcomes, and Therapeutics Research - Other
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Fatfat, Adnan, Mayo Clinic in Florida, Jacksonville, Florida, United States
- Batish, Ishaan, Mayo Clinic in Florida, Jacksonville, Florida, United States
- Sharma, Abhinav, Mayo Clinic in Florida, Jacksonville, Florida, United States
- Arevalo Salazar, Dory E., Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Albadri, Sam, Mayo Clinic Minnesota, Rochester, Minnesota, United States
- Aslam, Nabeel, Mayo Clinic in Florida, Jacksonville, Florida, United States
- Bobart, Shane A., Mayo Clinic in Florida, Jacksonville, Florida, United States
Background
Neighborhood-level socioeconomic deprivation is associated with adverse outcomes in chronic kidney disease, but its relationship with IgA nephropathy (IgAN) outcomes remains poorly defined. We examined whether Area Deprivation Index (ADI), grouped into low, medium, and high deprivation categories, was associated with kidney outcomes in patients with biopsy-proven IgAN.
Methods
We conducted a retrospective cohort study of 218 adults with biopsy-proven IgAN across the Mayo Clinic Health System (2016-2025). ADI ranks U.S. neighborhoods from 1 (least deprived) to 100 (most deprived). Patients were stratified into ADI tertiles: low (n=73), medium (n=72), and high (n=73). Baseline demographic, clinical, laboratory, and histologic features, as well as 12-month clinical and laboratory characteristics, were compared across groups. The primary outcome was composite renal progression (death, dialysis, kidney transplant, or >40% decline in eGFR at 12 months. Secondary outcomes included proteinuria remission ≤0.5 g/day and eGFR change categories. Multivariable logistic regression examined the association between ADI group and outcomes, adjusting for age, sex, baseline eGFR, baseline proteinuria >1 g/day, and baseline immunosuppression.
Results
Demographic characteristics and MEST-C scores were similar across the 3 ADI groups. There were no significant differences in baseline or 12-month laboratory values or medications, although immunosuppression use was more frequent in the low ADI group compared to the medium and high ADI groups, particularly at 12 months (41.2% vs 29.7% vs 26.2%, respectively). Only 6 patients (8.4%) in the low ADI group had composite renal progression at 12 months, compared to 14 (19.4%) and 19 (26%) in medium and high ADI groups, respectively (p=0.018). Proteinuria remission and eGFR change categories at 12 months were comparable across groups. On multivariable analysis, high ADI was associated with 12-month renal progression (OR 3.11; 95% CI 1.01-9.62).
Conclusion
Despite similar baseline and follow-up characteristics across ADI strata, higher neighborhood deprivation was independently associated with worse short-term renal outcomes, underscoring the need to address socioeconomic disparities in IgAN care.